Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2321569..2322314 Replicon chromosome
Accession NZ_CP066101
Organism Enterobacter hormaechei strain Eho-8

Toxin (Protein)


Gene name tacT Uniprot ID F5RXF6
Locus tag GVI69_RS11130 Protein ID WP_006810665.1
Coordinates 2321823..2322314 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7T1VGI8
Locus tag GVI69_RS11125 Protein ID WP_032673836.1
Coordinates 2321569..2321835 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI69_RS11105 (GVI69_11080) 2317046..2318032 + 987 WP_006810670.1 DUF979 domain-containing protein -
GVI69_RS11110 (GVI69_11085) 2318042..2319037 + 996 WP_006810669.1 DUF2891 domain-containing protein -
GVI69_RS11115 (GVI69_11090) 2319058..2320446 - 1389 WP_039273807.1 MFS transporter -
GVI69_RS11120 (GVI69_11095) 2320575..2321480 + 906 WP_032673837.1 LysR family transcriptional regulator -
GVI69_RS11125 (GVI69_11100) 2321569..2321835 + 267 WP_032673836.1 DUF1778 domain-containing protein Antitoxin
GVI69_RS11130 (GVI69_11105) 2321823..2322314 + 492 WP_006810665.1 GNAT family N-acetyltransferase Toxin
GVI69_RS11135 (GVI69_11110) 2322353..2323351 - 999 WP_006810664.1 HAD family hydrolase -
GVI69_RS11140 (GVI69_11115) 2323348..2324361 - 1014 WP_006810663.1 BatD family protein -
GVI69_RS11145 (GVI69_11120) 2324358..2325872 - 1515 WP_006810662.1 VWA domain-containing protein -
GVI69_RS11150 (GVI69_11125) 2325869..2326846 - 978 WP_039273812.1 VWA domain-containing protein -
GVI69_RS11155 (GVI69_11130) 2326839..2327279 - 441 WP_006810660.1 DUF4381 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(45-151)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17773.46 Da        Isoelectric Point: 9.6044

>T183943 WP_006810665.1 NZ_CP066101:2321823-2322314 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK

Download         Length: 492 bp

>T183943 NZ_CP087273:c110170-109688 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT183943 WP_032673836.1 NZ_CP066101:2321569-2321835 [Enterobacter hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT183943 NZ_CP087273:c110424-110158 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7T1VG35


Antitoxin

Source ID Structure
AlphaFold DB A0A7T1VGI8

References