Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 2321569..2322314 | Replicon | chromosome |
Accession | NZ_CP066101 | ||
Organism | Enterobacter hormaechei strain Eho-8 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | F5RXF6 |
Locus tag | GVI69_RS11130 | Protein ID | WP_006810665.1 |
Coordinates | 2321823..2322314 (+) | Length | 164 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | A0A7T1VGI8 |
Locus tag | GVI69_RS11125 | Protein ID | WP_032673836.1 |
Coordinates | 2321569..2321835 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GVI69_RS11105 (GVI69_11080) | 2317046..2318032 | + | 987 | WP_006810670.1 | DUF979 domain-containing protein | - |
GVI69_RS11110 (GVI69_11085) | 2318042..2319037 | + | 996 | WP_006810669.1 | DUF2891 domain-containing protein | - |
GVI69_RS11115 (GVI69_11090) | 2319058..2320446 | - | 1389 | WP_039273807.1 | MFS transporter | - |
GVI69_RS11120 (GVI69_11095) | 2320575..2321480 | + | 906 | WP_032673837.1 | LysR family transcriptional regulator | - |
GVI69_RS11125 (GVI69_11100) | 2321569..2321835 | + | 267 | WP_032673836.1 | DUF1778 domain-containing protein | Antitoxin |
GVI69_RS11130 (GVI69_11105) | 2321823..2322314 | + | 492 | WP_006810665.1 | GNAT family N-acetyltransferase | Toxin |
GVI69_RS11135 (GVI69_11110) | 2322353..2323351 | - | 999 | WP_006810664.1 | HAD family hydrolase | - |
GVI69_RS11140 (GVI69_11115) | 2323348..2324361 | - | 1014 | WP_006810663.1 | BatD family protein | - |
GVI69_RS11145 (GVI69_11120) | 2324358..2325872 | - | 1515 | WP_006810662.1 | VWA domain-containing protein | - |
GVI69_RS11150 (GVI69_11125) | 2325869..2326846 | - | 978 | WP_039273812.1 | VWA domain-containing protein | - |
GVI69_RS11155 (GVI69_11130) | 2326839..2327279 | - | 441 | WP_006810660.1 | DUF4381 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17773.46 Da Isoelectric Point: 9.6044
>T183943 WP_006810665.1 NZ_CP066101:2321823-2322314 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK
Download Length: 492 bp
>T183943 NZ_CP087273:c110170-109688 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.50 Da Isoelectric Point: 4.3837
>AT183943 WP_032673836.1 NZ_CP066101:2321569-2321835 [Enterobacter hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV
Download Length: 267 bp
>AT183943 NZ_CP087273:c110424-110158 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T1VG35 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T1VGI8 |