Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4103735..4104392 Replicon chromosome
Accession NZ_CP066094
Organism Enterobacter hormaechei strain Eho-E1

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag I9464_RS19975 Protein ID WP_017382887.1
Coordinates 4103735..4104145 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag I9464_RS19980 Protein ID WP_003863437.1
Coordinates 4104126..4104392 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9464_RS19955 (I9464_19935) 4099733..4101466 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
I9464_RS19960 (I9464_19940) 4101472..4102185 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I9464_RS19965 (I9464_19945) 4102214..4103110 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
I9464_RS19970 (I9464_19950) 4103212..4103733 + 522 WP_015571793.1 flavodoxin FldB -
I9464_RS19975 (I9464_19955) 4103735..4104145 - 411 WP_017382887.1 protein YgfX Toxin
I9464_RS19980 (I9464_19960) 4104126..4104392 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
I9464_RS19985 (I9464_19965) 4104687..4105667 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
I9464_RS19990 (I9464_19970) 4105779..4106438 - 660 WP_003863433.1 hemolysin III family protein -
I9464_RS19995 (I9464_19975) 4106705..4107436 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
I9464_RS20000 (I9464_19980) 4107553..4108986 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T183934 WP_017382887.1 NZ_CP066094:c4104145-4103735 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T183934 NZ_CP087272:736779-737264 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT183934 WP_003863437.1 NZ_CP066094:c4104392-4104126 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT183934 NZ_CP087272:736489-736782 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References