Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2605026..2605765 Replicon chromosome
Accession NZ_CP066094
Organism Enterobacter hormaechei strain Eho-E1

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag I9464_RS12625 Protein ID WP_017382345.1
Coordinates 2605026..2605511 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag I9464_RS12630 Protein ID WP_003857131.1
Coordinates 2605499..2605765 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9464_RS12600 (I9464_12580) 2600602..2601186 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
I9464_RS12605 (I9464_12585) 2601273..2602031 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
I9464_RS12610 (I9464_12590) 2602136..2603428 + 1293 WP_023303742.1 glycosyl hydrolase family 28 protein -
I9464_RS12615 (I9464_12595) 2603428..2604042 + 615 WP_023303743.1 NUDIX hydrolase -
I9464_RS12620 (I9464_12600) 2604406..2604975 + 570 WP_017382346.1 hypothetical protein -
I9464_RS12625 (I9464_12605) 2605026..2605511 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
I9464_RS12630 (I9464_12610) 2605499..2605765 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
I9464_RS12635 (I9464_12615) 2605829..2606758 - 930 WP_023303744.1 LysR family transcriptional regulator -
I9464_RS12640 (I9464_12620) 2606888..2608276 + 1389 WP_032619651.1 MFS transporter -
I9464_RS12645 (I9464_12625) 2608298..2609293 - 996 WP_023303746.1 DUF2891 domain-containing protein -
I9464_RS12650 (I9464_12630) 2609303..2610289 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T183922 WP_017382345.1 NZ_CP066094:c2605511-2605026 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T183922 NZ_CP087265:49139-49480 [Listeria monocytogenes]
ATGGTAAAGCAAGGCGATATTATCAAGATCAATCTAAATCCAAAACAGGGACACGAGCAGCAAGGCTATCGGCCCTATAT
TTGCCTCAGTCATCATCTGGTAAGTGATTATGCAAATATCGCGATCTTTGCCCCAATCAGTAATACACCGCGCACCTATC
CGTTATATGTGCCTTTGACAGGGACAACCACAACCGGAAAAGTATTGCTGGATCAACTAGTTACGATCGATTACAACGCT
CGTAAGCATCAATACGTGGAAACTGTTTCGGATCCATTGCTCACAAAGCTATTAGATACAGTAAAAGTTATTTTTCAAAA
GAACGAGAGATCAACCAACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT183922 WP_003857131.1 NZ_CP066094:c2605765-2605499 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT183922 NZ_CP087265:48903-49145 [Listeria monocytogenes]
ATGACCACCGTTAGCGTTAAAAAGTGGGGAAATAGCAAAGCTGTTCGTCTCCCCAATAATCTATTAAATGCCTTAGACAT
CAAAGAGAACGATGATTTGAAAGTGGAAGTGATCAATAATCAGATGATCCTTACCAAAACAGCTATCGATCTCCGAATCG
AGGATCTGTTTGCCAATTACCAGGGCGAACCCTTCCAAACTGAGCTGCAAACATTCGAACCAATCGGAGATGAAAAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References