Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1382733..1383353 Replicon chromosome
Accession NZ_CP066094
Organism Enterobacter hormaechei strain Eho-E1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag I9464_RS06660 Protein ID WP_015571250.1
Coordinates 1382733..1382951 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag I9464_RS06665 Protein ID WP_006809850.1
Coordinates 1382979..1383353 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9464_RS06630 (I9464_06620) 1378745..1379005 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
I9464_RS06635 (I9464_06625) 1379008..1379148 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I9464_RS06640 (I9464_06630) 1379145..1379855 - 711 WP_023303201.1 GNAT family protein -
I9464_RS06645 (I9464_06635) 1379957..1381417 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
I9464_RS06650 (I9464_06640) 1381389..1381856 - 468 WP_017383209.1 YlaC family protein -
I9464_RS06655 (I9464_06645) 1381973..1382524 - 552 WP_023303203.1 maltose O-acetyltransferase -
I9464_RS06660 (I9464_06650) 1382733..1382951 - 219 WP_015571250.1 HHA domain-containing protein Toxin
I9464_RS06665 (I9464_06655) 1382979..1383353 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
I9464_RS06670 (I9464_06660) 1383864..1387010 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
I9464_RS06675 (I9464_06665) 1387033..1388226 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T183921 WP_015571250.1 NZ_CP066094:c1382951-1382733 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T183921 NZ_CP087263:4848166-4848516 [Brevibacillus humidisoli]
GTGATAGTAAAACGTGGCGATGTATTTTTTGCGGACCTCTCACCTGTTGTCGGTTCTGAACAGGGGGGCGTGCGCCCAGT
ATTGGTGATCCAAAACGATATTGGAAATCGTTTTAGTCCGACTGTCATCGTCGCGGCTATCACGGCACAGATTCAAAAGG
CCAAACTGCCTACGCATGTAGAGATTGACGCCAAGTTATACGGATTTGATCGTGACTCCGTTATTCTGCTCGAGCAGATT
CGCACGATTGACAAACAGCGTCTCACCGACAAAATCACTCGCTTGGACGATGAGATGATGGAGCGTGTCAATGAATCGTT
GCAGATAAGTTTGGGTTTGATAGACTTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT183921 WP_006809850.1 NZ_CP066094:c1383353-1382979 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT183921 NZ_CP087263:4847851-4848162 [Brevibacillus humidisoli]
ATGTCATTGGGTCATGGTGGAGGTGGATTTGTCTTGTCGAAAACCAACACGAAGCGTATCATGATTAGCCTGCCGCAGCA
CCTGCTGCAGGAAGTGGACGGCGTGGTAGAGAAAGAGAAGTCCAATAGAAGCGAACTCATTCGTCAGGCAATGAGTCTTT
ATCTGAAGGAGCGTAAAAAGCGTTTTATCCGGGAAACGATGCAAAAAGGGTATATGGAGATGGCAAAAATCAATTTAAAT
ATGGCTTCGGAGGCATTTGAAGCAGAGGAAGAAGCCGACTTGACTTTGGACCGCTTAGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References