Detailed information of TA system TA183918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 1527204..1528438
• Replicon: chromosome
• Accession: NZ_CP066093
• Organism: Streptococcus salivarius strain FDAARGOS_1045

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: I6I02_RS06910
• Protein ID: WP_198463313.1
• Coordinates: 1527204..1527962 (-)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: I6I02_RS06915
• Protein ID: WP_198463314.1
• Coordinates: 1527962..1528438 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I02_RS06885	1523017..1523473	+	457	Protein_1360	helix-turn-helix domain-containing protein	-
I6I02_RS06890	1523539..1523693	-	155	Protein_1361	peptidylprolyl isomerase	-
I6I02_RS06895	1523825..1524817	+	993	WP_198463311.1	hypothetical protein	-
I6I02_RS06900	1524861..1525826	-	966	WP_073950870.1	polyprenyl synthetase family protein	-
I6I02_RS06905	1525917..1526813	+	897	WP_198463312.1	tyrosine-type recombinase/integrase	-
I6I02_RS06910	1527204..1527962	-	759	WP_198463313.1	zeta toxin family protein	Toxin
I6I02_RS06915	1527962..1528438	-	477	WP_198463314.1	helix-turn-helix domain-containing protein	Antitoxin
I6I02_RS06920	1528508..1528765	-	258	WP_198463315.1	hypothetical protein	-
I6I02_RS06925	1528792..1529328	-	537	WP_198463316.1	hypothetical protein	-
I6I02_RS06930	1529341..1529721	-	381	WP_070839262.1	hypothetical protein	-
I6I02_RS06935	1529714..1530037	-	324	WP_198463317.1	hypothetical protein	-
I6I02_RS06940	1531447..1532436	+	990	Protein_1371	transposase	-
I6I02_RS06945	1532679..1533383	-	705	WP_198463318.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1492470..1677617	185147

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28780.59 Da
• Isoelectric Point: 6.4156

>T183918 WP_198463313.1 NZ_CP066093:c1527962-1527204 [Streptococcus salivarius]
MEIQDYTGSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDLIVNNLVENTHQLEQLGIFEQIQIYQRDRTCVYDSRDDEISAATVLHELLFGEWSQVEKDML
KSGEERFKDLTN

Nucleotide

• Length: 759 bp

>T183918 NZ_CP087226:1712990-1713247 [Dickeya fangzhongdai]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTCTGCTACGGCAACCATGAGCTGATCATCAGTATTCGTACTGGAACAGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGCGCATATCAGAGCCCATCGGGAACAACTGCTGAGTATGTGGGAGCGGGCGGTTGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18128.63 Da
• Isoelectric Point: 4.6348

>AT183918 WP_198463314.1 NZ_CP066093:c1528438-1527962 [Streptococcus salivarius]
MIGKNIKSLRKTHGLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSNDLSDLIHTNIYLVETFGEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT183918 NZ_CP087226:1713255-1713743 [Dickeya fangzhongdai]
ATGCATAAAATCGTGGAAGTTGACGTGATTGGCGACTTTTCGTTGCGCCTGACCTATGAGGATGGTTTGGTTTGCGACAT
CAATCTTTATCAATATGCCTCCAGCCCGGTATTTTCGAACGCCAGCCTATTTATCAAGTTTGGGCTGCTGCCGGATGGTT
CGCTGGAATGGTCGCCGGATATTAAGATTTCCGCGTCGGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTTGCG
GTGCGAGAAAAGAACTTCGCTGATGTCATCTCTCGCGCCTTCTATGATGCCGTGATTGAGAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATCGCGGTGGAAAAACATGGCAACAGCACAGTAGCCAAAGAGGCGGGGGCGAAAAGTCGCACCAGTC
TGTATAAGTCGCTGAATAAAAATACCCATGTCAGTCTTGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAA