Detailed information of TA system TA183917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 674938..675397
• Replicon: chromosome
• Accession: NZ_CP066093
• Organism: Streptococcus salivarius strain FDAARGOS_1045

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7T4KDK6
• Locus tag: I6I02_RS02915
• Protein ID: WP_049554070.1
• Coordinates: 675143..675397 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6I02_RS02910
• Protein ID: WP_118185381.1
• Coordinates: 674938..675153 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I02_RS02890	670130..671296	+	1167	WP_060934054.1	galactokinase	-
I6I02_RS02895	671316..672797	+	1482	WP_064525316.1	UDP-glucose--hexose-1-phosphate uridylyltransferase	-
I6I02_RS02900	672827..673828	+	1002	WP_198463765.1	UDP-glucose 4-epimerase GalE	-
I6I02_RS02905	673963..674805	+	843	WP_198463766.1	aldo/keto reductase	-
I6I02_RS02910	674938..675153	+	216	WP_118185381.1	antitoxin	Antitoxin
I6I02_RS02915	675143..675397	+	255	WP_049554070.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I02_RS02920	675541..676227	+	687	WP_198463767.1	DUF1275 domain-containing protein	-
I6I02_RS02925	676318..676950	+	633	WP_198463768.1	nitroreductase family protein	-
I6I02_RS02930	677106..677789	+	684	WP_155222646.1	response regulator transcription factor	-
I6I02_RS02935	677789..678664	+	876	WP_198463769.1	HAMP domain-containing histidine kinase	-
I6I02_RS02940	678949..679458	+	510	WP_198463770.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9860.63 Da
• Isoelectric Point: 11.1183

>T183917 WP_049554070.1 NZ_CP066093:675143-675397 [Streptococcus salivarius]
MTYKIVPTPKFAKSFKKLDPFVRKQIKAYLNRVTENPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T183917 NZ_CP087226:1689842-1690156 [Dickeya fangzhongdai]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCATTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGTCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCCCTGGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATCGACGGCATTTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8031.00 Da
• Isoelectric Point: 3.8964

>AT183917 WP_118185381.1 NZ_CP066093:674938-675153 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTIEAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Nucleotide

• Length: 216 bp

>AT183917 NZ_CP087226:1689603-1689839 [Dickeya fangzhongdai]
ATGACCGCGAAACAACGCAACACACAGAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
GATTAACCTGAGTGCCACCCTGTCAACCGCCCTGGATGCAGAGCTTCGCCACCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAGGCCATCGACGCATTAAATCGTTTTCATGATGAGCAGGGGTGTTTCAGCGATGAATACCGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: A0A7T4KDK6