Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3683586..3684240 Replicon chromosome
Accession NZ_CP066089
Organism Citrobacter koseri strain FDAARGOS_1029

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag I6H86_RS17295 Protein ID WP_024130921.1
Coordinates 3683833..3684240 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag I6H86_RS17290 Protein ID WP_024130922.1
Coordinates 3683586..3683852 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H86_RS17265 3678727..3680160 - 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -
I6H86_RS17270 3680281..3681009 - 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
I6H86_RS17275 3681062..3681373 + 312 WP_012135005.1 N(4)-acetylcytidine aminohydrolase -
I6H86_RS17280 3681535..3682194 + 660 WP_012135004.1 hemolysin III family protein -
I6H86_RS17285 3682349..3683329 - 981 WP_024130923.1 tRNA-modifying protein YgfZ -
I6H86_RS17290 3683586..3683852 + 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
I6H86_RS17295 3683833..3684240 + 408 WP_024130921.1 protein YgfX Toxin
I6H86_RS17300 3684338..3684862 - 525 WP_012134999.1 flavodoxin FldB -
I6H86_RS17305 3684966..3685862 + 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
I6H86_RS17310 3685886..3686599 + 714 WP_012134997.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6H86_RS17315 3686605..3688338 + 1734 WP_012134996.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T183914 WP_024130921.1 NZ_CP066089:3683833-3684240 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

>T183914 NZ_CP087226:714850-715281 [Dickeya fangzhongdai]
GTGGCCCAGTGGCAATGTGATTTGCGTGTATCCTGGCGCATGCAGTTGTTTTCTCTGCTGACGCACGGGTTCCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACCGGCAAAGGGCA
TCAGCGCCTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAATGGCGGCTGTTGCGCCAGCTGTTGCAGCAGCACCCGC
TGCAGGGAACTGAATCTTCCCGCCATCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT183914 WP_024130922.1 NZ_CP066089:3683586-3683852 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT183914 NZ_CP087226:714603-714869 [Dickeya fangzhongdai]
ATGGACATCAATAACAAATCACGCATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATTTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGTGGATCCGGAGCTGAAGCGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References