Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1579793..1580413 | Replicon | chromosome |
Accession | NZ_CP066089 | ||
Organism | Citrobacter koseri strain FDAARGOS_1029 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | I6H86_RS07475 | Protein ID | WP_002892050.1 |
Coordinates | 1580195..1580413 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A8AJY4 |
Locus tag | I6H86_RS07470 | Protein ID | WP_012133514.1 |
Coordinates | 1579793..1580167 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6H86_RS07460 | 1574929..1576122 | + | 1194 | WP_012133512.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
I6H86_RS07465 | 1576145..1579291 | + | 3147 | WP_012133513.1 | efflux RND transporter permease AcrB | - |
I6H86_RS07470 | 1579793..1580167 | + | 375 | WP_012133514.1 | Hha toxicity modulator TomB | Antitoxin |
I6H86_RS07475 | 1580195..1580413 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
I6H86_RS07480 | 1580597..1581148 | + | 552 | WP_012133515.1 | maltose O-acetyltransferase | - |
I6H86_RS07485 | 1581262..1581732 | + | 471 | WP_024130587.1 | membrane protein | - |
I6H86_RS07490 | 1581810..1581950 | - | 141 | WP_003859006.1 | type B 50S ribosomal protein L36 | - |
I6H86_RS07495 | 1581952..1582212 | - | 261 | WP_012133519.1 | type B 50S ribosomal protein L31 | - |
I6H86_RS07500 | 1582438..1583988 | + | 1551 | WP_024130588.1 | EAL domain-containing protein | - |
I6H86_RS07505 | 1584028..1584381 | - | 354 | WP_012133521.1 | DUF1428 family protein | - |
I6H86_RS07510 | 1584461..1585075 | - | 615 | WP_012133522.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 1579793..1587837 | 8044 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T183911 WP_002892050.1 NZ_CP066089:1580195-1580413 [Citrobacter koseri]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T183911 NZ_CP087205:c6857526-6857248 [Pseudomonas sp. B21-053]
ATGATCGTTAGCTTTAAGTGTTCTGAGACCGAGTACCTGTTTCGCAACGGTAAGACCCGTATGTGGTCAGCCCTTCTGAA
TGTCGTGGAACGAAAGCTGACGATGCTTGATGCTGCTGCCGTTCTGATGGACCTTCGATCACCGCCGGGCAATCGCTTGG
AGGCGTTGGAGGGGAGTCGAAAAGGTCAGTACAGCATCCGAATCAACGCTCAATGGCGAATTTGCTTTGTATGGGGTCCT
AGCGGACCAGAGAATGTCGAAATCGTCGATTATCACTGA
ATGATCGTTAGCTTTAAGTGTTCTGAGACCGAGTACCTGTTTCGCAACGGTAAGACCCGTATGTGGTCAGCCCTTCTGAA
TGTCGTGGAACGAAAGCTGACGATGCTTGATGCTGCTGCCGTTCTGATGGACCTTCGATCACCGCCGGGCAATCGCTTGG
AGGCGTTGGAGGGGAGTCGAAAAGGTCAGTACAGCATCCGAATCAACGCTCAATGGCGAATTTGCTTTGTATGGGGTCCT
AGCGGACCAGAGAATGTCGAAATCGTCGATTATCACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14437.27 Da Isoelectric Point: 5.1444
>AT183911 WP_012133514.1 NZ_CP066089:1579793-1580167 [Citrobacter koseri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT183911 NZ_CP087205:c6857239-6856934 [Pseudomonas sp. B21-053]
ATGACTAAAAACGGTATGCGCCCGGTCCACCCCGGCGAGATCCTCAAAGAGGAATACCTTGAGCCACTGAGCCTTACAGC
GGCGGCTTTGGCCAGAGCATTGAGCGTTTCGACACCGACGGTGAATGACATCGTGCTTCAGCGTCGAGGCGTCAGTGCTG
ATATGGCTCTCAGATTATCTATCTGCCTGGACACGACTCCCGAGTTTTGGCTGAACCTGCAATCGACTTACGATTTGCGT
AAAGCCGAAATTGAACGAGGGGCTGCGATTCGGGATCAGGTTGAGCGTCTTGCGCACTGCGCCTGA
ATGACTAAAAACGGTATGCGCCCGGTCCACCCCGGCGAGATCCTCAAAGAGGAATACCTTGAGCCACTGAGCCTTACAGC
GGCGGCTTTGGCCAGAGCATTGAGCGTTTCGACACCGACGGTGAATGACATCGTGCTTCAGCGTCGAGGCGTCAGTGCTG
ATATGGCTCTCAGATTATCTATCTGCCTGGACACGACTCCCGAGTTTTGGCTGAACCTGCAATCGACTTACGATTTGCGT
AAAGCCGAAATTGAACGAGGGGCTGCGATTCGGGATCAGGTTGAGCGTCTTGCGCACTGCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A8AJY4 |