Detailed information of TA system TA183909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 508355..508994
• Replicon: chromosome
• Accession: NZ_CP066089
• Organism: Citrobacter koseri strain FDAARGOS_1029

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A381H3Z1
• Locus tag: I6H86_RS02360
• Protein ID: WP_071818852.1
• Coordinates: 508355..508531 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I6H86_RS02365
• Protein ID: WP_012132350.1
• Coordinates: 508578..508994 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H86_RS02340	503446..504321	+	876	WP_012132344.1	AraC family transcriptional regulator	-
I6H86_RS02345	504298..505464	-	1167	WP_012132345.1	benzoate/H(+) symporter BenE family transporter	-
I6H86_RS02350	505557..506093	+	537	WP_012132346.1	XRE family transcriptional regulator	-
I6H86_RS02355	506172..508133	+	1962	WP_012132347.1	U32 family peptidase	-
I6H86_RS02360	508355..508531	+	177	WP_071818852.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6H86_RS02365	508578..508994	+	417	WP_012132350.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6H86_RS02370	509046..510455	+	1410	WP_012132351.1	PLP-dependent aminotransferase family protein	-
I6H86_RS02375	510774..512198	+	1425	WP_012132353.1	aminobutyraldehyde dehydrogenase	-
I6H86_RS02380	512297..512392	-	96	WP_071818853.1	stress response membrane protein YncL	-
I6H86_RS02385	512584..512757	+	174	WP_048902428.1	GhoT/OrtT family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (82-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.81 Da
• Isoelectric Point: 10.8122

>T183909 WP_071818852.1 NZ_CP066089:508355-508531 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQLGLN

Nucleotide

• Length: 177 bp

>T183909 NZ_CP087205:4410635-4410928 [Pseudomonas sp. B21-053]
ATGAACTATCTTATTCAACAAACACATACTTTCTCGGCATGGCACGTCTCAGTTCGTGACTTACGGGCAAAGTTCGCCAT
CGCTCGTCGCATTGATCGTGCCTCTGCGGGTAATCTAGGCGACATCAAGTCGCTGGGTGATGGTGTTTCCGAAATGCGCG
TGGACATTGGTGCAGGCTATCGAATCTACTTCACCATGCGAAACGGCGTGGTCATCGTATTATTGGCCGGCGGCGACAAA
TCCTCGCAAAGCTCTGATATCCGGCGTGCAAAAAAAATGGCAAAGGAGGTTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15342.61 Da
• Isoelectric Point: 4.4377

>AT183909 WP_012132350.1 NZ_CP066089:508578-508994 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAAKALGKELSLTML

Nucleotide

• Length: 417 bp

>AT183909 NZ_CP087205:4410931-4411239 [Pseudomonas sp. B21-053]
ATGAGCCAAACTTTGACGACATTCGACATGGCAGCGCTGCTCGACAGTGATGAGGCCATCAGCGAATATCTCTCCCAGGT
ACTGGCAGAGGGCGACAACGAAGAGTTTCTCCGCGCTATCGGCTACGTGGTAAAAGCCCGTGGTATGACACAAATCGCCA
AAGATTCCGGGATGGGGCGCGAAAGCCTCTACAAGGCCTTCGCTCCGGGTGCAAAACCACGTTTTGATACGGTGCTAAAG
GTCATTCACGCCCTCGGAATTGATCTCTATGCGCAGCCAGGTCACAACCTCAATCATTCGAATCTCTGA

Structures

Toxin

• AlphaFold DB: A0A381H3Z1