Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4472331..4472950 Replicon chromosome
Accession NZ_CP066085
Organism Escherichia fergusonii strain FDAARGOS_1032

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag I6H89_RS21415 Protein ID WP_001280991.1
Coordinates 4472732..4472950 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag I6H89_RS21410 Protein ID WP_000344803.1
Coordinates 4472331..4472705 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H89_RS21400 4467463..4468656 + 1194 WP_015953614.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6H89_RS21405 4468679..4471828 + 3150 WP_001132491.1 efflux RND transporter permease AcrB -
I6H89_RS21410 4472331..4472705 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
I6H89_RS21415 4472732..4472950 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
I6H89_RS21420 4473447..4473917 + 471 WP_002431406.1 YlaC family protein -
I6H89_RS21425 4474056..4475606 + 1551 WP_001260376.1 EAL domain-containing protein -
I6H89_RS21430 4475648..4476001 - 354 WP_000878140.1 DUF1428 domain-containing protein -
I6H89_RS21440 4476380..4476691 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4476792..4478120 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T183900 WP_001280991.1 NZ_CP066085:4472732-4472950 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T183900 NZ_CP087204:1162838-1163182 [Pseudomonas sp. B21-054]
ATGCGTACCCTATTTTTTGAAACGACTACGTTCACCGCCACGGTTGGCCATTACCTGACTGACGATGAATATCGCCTGCT
TCAGTCCTATATGCTGCAGCATCCAGAGGTTGGTGACGTCATGCCACGAACCGGCGGCTTTCGTAAGCTGCGCTGGTTCG
ATGAACGTCGTGGCAAAGGGAAGCGAGGTGGGTTGCGAGTCATTTACTATTGGCTCATGAATGATCGTCAGTTCTGGATG
TTTGCGATTTATGACAAGGACGAGTTGGAAAACCTGACCTCCGAGCAAGAGAAGACGCTCAAGCGCGCCATAGAAGCTGA
GTTGAAAGTGCGAGGTACCTTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT183900 WP_000344803.1 NZ_CP066085:4472331-4472705 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT183900 NZ_CP087204:1163179-1163493 [Pseudomonas sp. B21-054]
ATGAAAAAACGTGATCTGTTTGCCGAGATGATGCAAGGCGTCGGGGAGATGGCCGCTCAACGGGAGGGCAAGATTACCCT
TCGCCAGATATCGATCGAAGACAAACCGGTTCCCGAGGTGTCGGCGCAGGAAATCGTAGCGTTGCGCGACAAGCTCCATA
TGTCTCAGGCCGTTTTTGCCAAGAGCATCAGGACCAGTCCTGGCACCCTTAGAAACTGGGAGCAGGAGAAGTCCAAACCC
AATGCCCAGGCGGCTCTTCTGATCAGGCTGGTCGAGAAGTTTCCAGACATGGTTGAGCGGCTCGGAGCGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References