Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 322747..323269 Replicon chromosome
Accession NZ_CP066078
Organism Rothia kristinae strain FDAARGOS_1001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6H58_RS01480 Protein ID WP_198490558.1
Coordinates 323000..323269 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag I6H58_RS01475 Protein ID WP_198490557.1
Coordinates 322747..323007 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H58_RS01450 317811..318377 - 567 WP_198490552.1 HIT domain-containing protein -
I6H58_RS01455 318492..318998 + 507 WP_198490553.1 FBP domain-containing protein -
I6H58_RS01460 319077..321092 - 2016 WP_198490554.1 threonine--tRNA ligase -
I6H58_RS01465 321245..322174 - 930 WP_198490555.1 hypothetical protein -
I6H58_RS01470 322072..322500 - 429 WP_198490556.1 hypothetical protein -
I6H58_RS01475 322747..323007 + 261 WP_198490557.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6H58_RS01480 323000..323269 + 270 WP_198490558.1 Txe/YoeB family addiction module toxin Toxin
I6H58_RS01485 323297..326740 - 3444 WP_198490559.1 PHP domain-containing protein -
I6H58_RS01490 326773..327524 - 752 Protein_288 3-keto-5-aminohexanoate cleavage protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10873.35 Da        Isoelectric Point: 8.9208

>T183871 WP_198490558.1 NZ_CP066078:323000-323269 [Rothia kristinae]
MPDLLLTWDPEAWEDYLWWQRQDRAVLRRINTLIRDIQRHGNEGIGKPEPLRHDFAGYWSRRITAEHRLVYRLTDRQVLI
AACRYHYGQ

Download         Length: 270 bp

>T183871 NZ_CP087198:330805-330987 [Pseudomonas sp. B21-010]
ATGCGAAGTCGGGAAATGATCAGGAAGATCGAAGAGGATGGTTGGTATCTAGTGGCAATCAAGGGTAGCCATCACCAGTA
CAAACACGCCTTCAAGGCTGGGAGGGTGACGATCAAACACCCTGACGCCGATCTGCCCAGAGGCACGATCAATAGCATAT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9672.87 Da        Isoelectric Point: 5.1312

>AT183871 WP_198490557.1 NZ_CP066078:322747-323007 [Rothia kristinae]
VKTMTYTESRARYAEVLDGVVQDREEVVITRSGHDPVVILSLAEYESLKETAHLLRSPANARRLLDAMQRLEAGQGQRHE
LVDPDA

Download         Length: 261 bp

>AT183871 NZ_CP087198:331080-331481 [Pseudomonas sp. B21-010]
ATGAAATTTCCGGTCGTTCTGCACAAGGATGCCGATTCCGAATACGGAGTGACGGTCCCGGATGTACCGGGTTGTTTCTC
CGCCGGCAGTACCGTGAGCCAGGCATTCGAAAATGTGAAAGAAGCGCTCTCGTTGCACTATGAAGGCTTGATAGCCGACG
GCGAGCCGCTGCCGCAGATCCATGAAATTGACGATCATCTCGACGATCCGCAATACGCCGGTGGGATATGGGGGGTGGTT
GAGTTTGATGTCACGCCCTATTTCGGGAAATCAGTGCGGTTCAACGCCACGCTGCCCGAGCAATTGCTTGAGCGCATCGA
CCAAACCGTGCGACGGGATCAGCGTTATAGCTCGCGTTCGGGTTTCCTGGCAGCGGCGGCCTTGCGCGAACTTTCAGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References