Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 2512017..2513807 | Replicon | chromosome |
| Accession | NZ_CP066076 | ||
| Organism | Paraburkholderia ginsengisoli strain FDAARGOS_1049 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A7T4TBL1 |
| Locus tag | I6I06_RS27860 | Protein ID | WP_042326545.1 |
| Coordinates | 2512905..2513807 (-) | Length | 301 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A7T4TB78 |
| Locus tag | I6I06_RS27855 | Protein ID | WP_042326543.1 |
| Coordinates | 2512017..2512904 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6I06_RS27835 | 2507195..2508685 | - | 1491 | WP_042326539.1 | aldehyde dehydrogenase | - |
| I6I06_RS27840 | 2508734..2509564 | - | 831 | WP_042326540.1 | aspartate dehydrogenase | - |
| I6I06_RS27845 | 2509557..2511215 | - | 1659 | WP_042326541.1 | thiamine pyrophosphate-binding protein | - |
| I6I06_RS27850 | 2511208..2512020 | - | 813 | WP_042326542.1 | SDR family oxidoreductase | - |
| I6I06_RS27855 | 2512017..2512904 | - | 888 | WP_042326543.1 | IclR family transcriptional regulator | Antitoxin |
| I6I06_RS27860 | 2512905..2513807 | - | 903 | WP_042326545.1 | alpha/beta fold hydrolase | Toxin |
| I6I06_RS27865 | 2513876..2514403 | - | 528 | WP_042326546.1 | cupin domain-containing protein | - |
| I6I06_RS27870 | 2514431..2515198 | - | 768 | WP_042326548.1 | SDR family oxidoreductase | - |
| I6I06_RS27875 | 2515191..2516282 | - | 1092 | WP_042326549.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| I6I06_RS27880 | 2516342..2516653 | - | 312 | WP_042326550.1 | hypothetical protein | - |
| I6I06_RS27885 | 2516655..2516969 | - | 315 | WP_042326551.1 | non-heme iron oxygenase ferredoxin subunit | - |
| I6I06_RS27890 | 2517407..2518480 | + | 1074 | WP_042326552.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 301 a.a. Molecular weight: 31148.24 Da Isoelectric Point: 7.4791
>T183870 WP_042326545.1 NZ_CP066076:c2513807-2512905 [Paraburkholderia ginsengisoli]
MSAVPSATADQPATLEARLARFPARQVSLASQRTLSYREAGSAGNSANSDALPLVLLHGIGSGAASWVQQFEGLGANRRV
LAWDAPGYGASTPVAAESPVAVDYAGVLKEWLDALGLERCVLVGHSLGAIIAGAFAAAHPQFVAGLLLLSPAGGYGAASA
EVRETKRDQRLAMLNELGPQGLAEKRSANMLSAHANDEARAWVRWNMSRVIPHGYAQATHLLANADLAADLSRFKGRINV
AVGADDTITPPAACERIALAAGTKLQVVPHAGHAGYIEAPAAYTAIIDTFCRASGGQRSQ
MSAVPSATADQPATLEARLARFPARQVSLASQRTLSYREAGSAGNSANSDALPLVLLHGIGSGAASWVQQFEGLGANRRV
LAWDAPGYGASTPVAAESPVAVDYAGVLKEWLDALGLERCVLVGHSLGAIIAGAFAAAHPQFVAGLLLLSPAGGYGAASA
EVRETKRDQRLAMLNELGPQGLAEKRSANMLSAHANDEARAWVRWNMSRVIPHGYAQATHLLANADLAADLSRFKGRINV
AVGADDTITPPAACERIALAAGTKLQVVPHAGHAGYIEAPAAYTAIIDTFCRASGGQRSQ
Download Length: 903 bp
>T183870 NZ_CP087197:5428799-5429137 [Pseudomonas sp. B21-012]
ATGGACGCACTTTTCGTCGAACTACCGGCCTTTGCGCGCTATCGCAGTGACTACCTGGATGACGAGGCGATGAGGGCCTT
GCAGCTCGTATTGCTGCTCAATCCTCAGGCCGGCTCAGTCATCCAGGGGACCGGGGGCTTGCGCAAAGTTCGCTTTGCTG
ATGATCAGCGGCACAAGGGCAAGCGCGGTGGAATCCGAGTCATCTATTACTGGTGGAGCAACGGCCAACAGTTCTGGCTG
TTCACCTTGTACGGCAAGGATCAACTGGACGACCTGAGCCCTGCGCAACGCCATTCGCTCAAACAGATGCTCGATCTGCA
AATCGAAGCGAGGAGATAA
ATGGACGCACTTTTCGTCGAACTACCGGCCTTTGCGCGCTATCGCAGTGACTACCTGGATGACGAGGCGATGAGGGCCTT
GCAGCTCGTATTGCTGCTCAATCCTCAGGCCGGCTCAGTCATCCAGGGGACCGGGGGCTTGCGCAAAGTTCGCTTTGCTG
ATGATCAGCGGCACAAGGGCAAGCGCGGTGGAATCCGAGTCATCTATTACTGGTGGAGCAACGGCCAACAGTTCTGGCTG
TTCACCTTGTACGGCAAGGATCAACTGGACGACCTGAGCCCTGCGCAACGCCATTCGCTCAAACAGATGCTCGATCTGCA
AATCGAAGCGAGGAGATAA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32691.26 Da Isoelectric Point: 7.4004
>AT183870 WP_042326543.1 NZ_CP066076:c2512904-2512017 [Paraburkholderia ginsengisoli]
MTPDTLNAERDAGDDRTDTGSEGGYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRTDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAY
ATTHGQVLMGDMTLDDLKKLYPEPELERFTKQTPATVEDLYERILDDARRGFAISESSFERGISVVSAPVRNDTGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPKTGPNAGSKYMKALGLR
MTPDTLNAERDAGDDRTDTGSEGGYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRTDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAY
ATTHGQVLMGDMTLDDLKKLYPEPELERFTKQTPATVEDLYERILDDARRGFAISESSFERGISVVSAPVRNDTGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPKTGPNAGSKYMKALGLR
Download Length: 888 bp
>AT183870 NZ_CP087197:5429139-5429453 [Pseudomonas sp. B21-012]
ATGAAACGCGATGTTTTTTCCGAACTGAACGAAGGCTTCGATGCCCTTGCCCAGGAGCGTCAGGGCAAACTGACCCTGCG
CTCGCATAAAGTACAGCTCGCCGAGTTGATGGACGTCTCGGCCGAAGAGCTTGTGGCTATTCGCGAACGCTTGAACATGT
CTCGCGCGGTATTTGCCATGTACCTGCGCACCAATGCCCGCACCCTGGAAAACTGGGAACAGGGCCGGGCCCGCCCCAAT
GCCCAGGCAATGACGCTGATTCGCCTGGTAGAAAAATTCCCTGAAACCGTGGAGCACCTGGCTGCGCTGGCCTGA
ATGAAACGCGATGTTTTTTCCGAACTGAACGAAGGCTTCGATGCCCTTGCCCAGGAGCGTCAGGGCAAACTGACCCTGCG
CTCGCATAAAGTACAGCTCGCCGAGTTGATGGACGTCTCGGCCGAAGAGCTTGTGGCTATTCGCGAACGCTTGAACATGT
CTCGCGCGGTATTTGCCATGTACCTGCGCACCAATGCCCGCACCCTGGAAAACTGGGAACAGGGCCGGGCCCGCCCCAAT
GCCCAGGCAATGACGCTGATTCGCCTGGTAGAAAAATTCCCTGAAACCGTGGAGCACCTGGCTGCGCTGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7T4TBL1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7T4TB78 |