Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 814524..815233 Replicon chromosome
Accession NZ_CP066076
Organism Paraburkholderia ginsengisoli strain FDAARGOS_1049

Toxin (Protein)


Gene name vagD Uniprot ID A0A7T4TBS7
Locus tag I6I06_RS20345 Protein ID WP_042328124.1
Coordinates 814524..814976 (-) Length 151 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A7T4N8Q4
Locus tag I6I06_RS20350 Protein ID WP_042328123.1
Coordinates 814973..815233 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I06_RS20325 809566..810087 + 522 WP_052400507.1 OmpA family protein -
I6I06_RS20330 810484..812928 + 2445 WP_167335673.1 EAL domain-containing protein -
I6I06_RS20335 812928..813662 + 735 WP_042328126.1 TenA family transcriptional regulator -
I6I06_RS20340 813966..814466 + 501 WP_157004250.1 hypothetical protein -
I6I06_RS20345 814524..814976 - 453 WP_042328124.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I06_RS20350 814973..815233 - 261 WP_042328123.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I06_RS20355 815453..817690 - 2238 WP_042328122.1 NADP-dependent isocitrate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 16377.91 Da        Isoelectric Point: 7.8309

>T183868 WP_042328124.1 NZ_CP066076:c814976-814524 [Paraburkholderia ginsengisoli]
VTQLYMLDTSICSLVVRERPQCILARLQACNAQQRIVISAITYAEMRFASAGKIDSPTHAQLVSAFVARLDGVLPWDAMA
ADRTIRVRVELAHLGAPISENDAAIAGHALAVGAILVTNNAREFRHVRGLHIEDWAKPAVSQRATEPEKL

Download         Length: 453 bp

>T183868 NZ_CP087197:3089214-3089396 [Pseudomonas sp. B21-012]
GTGCAAAGCAGGCAGTTGATAAAGGAGCTTGAAGCGGCTGGATGGGTTCTAAAGCGAGTCACTGGAAGCCACCACATCTT
CAAGCACCCCAACAACCCAAACTCGATACCAGTGCCTCACCCAAAGAAAGATCTACCGATAGGCACGGTAAAGAGCATCA
AGGAACGAGCCGGGTTGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9647.84 Da        Isoelectric Point: 5.1213

>AT183868 WP_042328123.1 NZ_CP066076:c815233-814973 [Paraburkholderia ginsengisoli]
MRTVSIFKNSTSQAVRIPKDMRFEGVTELEIRREGDTILLRPARPSWISFADEPRADADFMSGRAAVFRAGRYDLPDAVD
AQESAS

Download         Length: 261 bp

>AT183868 NZ_CP087197:3089434-3089835 [Pseudomonas sp. B21-012]
ATGCAATATCCAATCTGTATCGAGTGGGGCGACGAGAACACCGCTATCGGCATCCAGGTGCCGGACATTCCAGGCGCTGT
AACCGCAGGCGACACCTTCGAGGAGGCTTATACCGCCGCAGTCGAGGTCGCGCACATCATGCTCGAGGAGATCGCTTCGA
ATGGCCAGGCCATTCCCATGCCGACCACTGCCGCAACGCACCGGAGCAATCCAGACTTCGCGGATATGGGCTGGGGCATG
ATTGAGATCGACATTACGCCGTACCTGGGCAAGACCGAGAAGGTCAACGTGACCCTGCCTGGCTTTGTCATCCAGCGGAT
CGATCGGTACGTGCGCGATCACAATGTCAAAAGCCGTTCGTCTTTCCTCGCCGATGCGGCAATGGAAAAGCTTGGCAGGT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4TBS7

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4N8Q4

References