Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 30769..31328 Replicon plasmid unnamed
Accession NZ_CP066072
Organism Providencia stuartii strain FDAARGOS_1040

Toxin (Protein)


Gene name relE Uniprot ID A0A427HAI4
Locus tag I6H97_RS19915 Protein ID WP_038601436.1
Coordinates 31050..31328 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8VTV0
Locus tag I6H97_RS19910 Protein ID WP_038601434.1
Coordinates 30769..31050 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H97_RS19885 26542..27162 + 621 WP_038601426.1 type-F conjugative transfer system pilin assembly protein TrbC -
I6H97_RS19890 27159..29039 + 1881 WP_038601428.1 conjugal transfer protein TraN -
I6H97_RS19895 29036..29824 + 789 WP_038601430.1 type-F conjugative transfer system pilin assembly protein TraF -
I6H97_RS19900 29835..30137 + 303 WP_038601432.1 hypothetical protein -
I6H97_RS19905 30155..30667 + 513 WP_102781171.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
I6H97_RS19910 30769..31050 + 282 WP_038601434.1 ribbon-helix-helix domain-containing protein Antitoxin
I6H97_RS19915 31050..31328 + 279 WP_038601436.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H97_RS19920 31602..32000 + 399 WP_038601438.1 hypothetical protein -
I6H97_RS19925 32515..33891 + 1377 WP_038601440.1 F-type conjugal transfer protein TraH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48874 48874


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-50)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10787.42 Da        Isoelectric Point: 8.5045

>T183864 WP_038601436.1 NZ_CP066072:31050-31328 [Providencia stuartii]
MELKWTSKALSDLSRVYDFLAFSNTAAAARVVQTLTQAPVSLLVNNPRMGEQLFQFMPHEVRRVVVANYEVRYEIIDSTI
YILRIWHTREDR

Download         Length: 279 bp

>T183864 NZ_CP087196:c2400918-2400568 [Pseudomonas sp. B21-015]
ATGGATGCTCTTTTTATCGAATTACCTGCGTTTCAGAAACACCGCGATGACTATCTGGATGACGATCTGTTTCGCAGCTT
TCAGTTGGAGCTGCTAAAAAACCCCGAAGCGGGCGATCTCATTGAAGGCACGGGCGGGCTGCGAAAAATCCGCTTTTTCG
ATCAACGTCGCGGTAAAGGCAAGCGTAGCGGGCTTAGGGTGATTTATTACTGGTGGTCAGGTTTCGATCAATTCTGGCTG
TTCACCGTGTATAGCAAAAACGAGCAAGAAGACCTGTCGCCTGACCAGAAAAAACTTTTCAGACAAACGCTGGATAGAGA
AATCAACACGAGAACCCACTATGAAACGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10432.81 Da        Isoelectric Point: 5.6786

>AT183864 WP_038601434.1 NZ_CP066072:30769-31050 [Providencia stuartii]
MKNSSVQNSTKVLTAHVPLAMADKVDEIAARLERSRGWVMKQALSTWIAQEEMRDTLTREALSDVESGRVIDHQFVQDWA
ASLSSDQPLPVPR

Download         Length: 282 bp

>AT183864 NZ_CP087196:c2400578-2400264 [Pseudomonas sp. B21-015]
ATGAAACGTGACATTTTTTCCGAACTGATGGAAGGCCTCGAAGCCTTGGCTGACGAGCGCCAAGGCAAGGTCACGCTGCG
GACCCACAAGGTCAAGCTGCCGGAACTGGTACCCATCACTGCCGAGGAAGTGGTAGCCATCCGTCAACAGCTCAATCTTT
CCCGGTCGGTGTTCGCCATGTATCTACGCACCAACACCCGAACCCTCGAAAACTGGGAACAGGGACGGGCAACACCAAAT
GCCCAAGCCACGACACTGATCCGCTTGGTTGAACGCTTTCCGCAAACAATCGAACAACTCGCAGCGCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427HAI4

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8VTV0

References