Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4073288..4073945 Replicon chromosome
Accession NZ_CP066071
Organism Providencia stuartii strain FDAARGOS_1040

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag I6H97_RS18770 Protein ID WP_036941148.1
Coordinates 4073288..4073698 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag I6H97_RS18775 Protein ID WP_004921708.1
Coordinates 4073679..4073945 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H97_RS18750 4069175..4070908 - 1734 WP_004921693.1 single-stranded-DNA-specific exonuclease RecJ -
I6H97_RS18755 4070914..4071618 - 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6H97_RS18760 4071638..4072561 - 924 WP_004921697.1 site-specific tyrosine recombinase XerD -
I6H97_RS18765 4072724..4073242 + 519 WP_014656387.1 flavodoxin FldB -
I6H97_RS18770 4073288..4073698 - 411 WP_036941148.1 membrane protein Toxin
I6H97_RS18775 4073679..4073945 - 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
I6H97_RS18780 4074198..4075187 + 990 WP_004921711.1 tRNA-modifying protein YgfZ -
I6H97_RS18785 4075199..4075819 + 621 WP_004921714.1 HD domain-containing protein -
I6H97_RS18790 4076038..4078914 - 2877 WP_004921716.1 aminomethyl-transferring glycine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T183863 WP_036941148.1 NZ_CP066071:c4073698-4073288 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T183863 NZ_CP087195:c5604061-5603717 [Pseudomonas brassicacearum]
ATGCGTACCCTATTTTTTGAAACGACTACATTCACCGACACGGTTGGCCATTACCTGACTGATGATGAGTATCGCCTGCT
TCAGTCCTATATGCTGCAGCATCCAGAGGTTGGTGACGTCATGCCACGTACCGGCGGCTTTCGTAAGCTGCGCTGGTTCG
ATGAACGTCGTGGTAAAGGGAAGCGAGGCGGGTTGCGCGTTATTTACTATTGGCTCATGAACGATCGTCAGTTCTGGATG
TTCGCGATTTATGACAAGGACGAGTTGGAAAACCTGACCTCCGAGCAAGAGAAGACGCTCAAACGCGCCATAGAAGCTGA
GTTGAAAGTACGAGGTACCTTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT183863 WP_004921708.1 NZ_CP066071:c4073945-4073679 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT183863 NZ_CP087195:c5603720-5603406 [Pseudomonas brassicacearum]
ATGAAAAAGCGCGATCTGTTTGCCGAGATGATGCAAGGCGTCGAGGAGATGGCCGCCCACCGGGAGGGCAAGATTACCCT
TCGCCAGATATCGATCGAAGACAAACCGGTTCCCGAGGTGTCTGCCCAAGAAATCGTGGCGTTGCGCGACAAGCTCCACA
TGTCTCAAGCCGTTTTCGCCAAGAGCATCAGGACCAGTCCAGGTACGCTCAGGAACTGGGAGCAGGAGAAGTCCAAGCCT
AACGCCCAGGCGGCTTTGTTGATCAAGCTGGTCGAGAAGTTTCCAGATATGGTCGAACGGCTTGGCGCTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References