Detailed information of TA system TA183861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1805046..1806768
• Replicon: chromosome
• Accession: NZ_CP066071
• Organism: Providencia stuartii strain FDAARGOS_1040

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D0FZT9
• Locus tag: I6H97_RS08140
• Protein ID: WP_000356587.1
• Coordinates: 1805830..1806768 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A934MVJ4
• Locus tag: I6H97_RS08135
• Protein ID: WP_000095577.1
• Coordinates: 1805046..1805837 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H97_RS08105	1800719..1801000	+	282	WP_040132784.1	type IV conjugative transfer system protein TraL	-
I6H97_RS08110	1800997..1801623	+	627	WP_000667167.1	hypothetical protein	-
I6H97_RS08115	1801607..1802503	+	897	WP_040133420.1	type-F conjugative transfer system secretin TraK	-
I6H97_RS08120	1802506..1803795	+	1290	WP_040132785.1	TraB/VirB10 family protein	-
I6H97_RS08125	1803870..1804442	+	573	WP_144242666.1	TraV family lipoprotein	-
I6H97_RS08130	1804439..1804825	+	387	WP_032469918.1	hypothetical protein	-
I6H97_RS08135	1805046..1805837	+	792	WP_000095577.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6H97_RS08140	1805830..1806768	+	939	WP_000356587.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6H97_RS08145	1807291..1807947	-	657	WP_025611037.1	hypothetical protein	-
I6H97_RS08150	1807991..1808137	-	147	WP_162838621.1	hypothetical protein	-
I6H97_RS08155	1808379..1809071	+	693	WP_040132787.1	DsbC family protein	-
I6H97_RS08160	1809071..1811470	+	2400	WP_024008831.1	type IV secretion system protein TraC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35548.82 Da
• Isoelectric Point: 4.9081

>T183861 WP_000356587.1 NZ_CP066071:1805830-1806768 [Providencia stuartii]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T183861 NZ_CP087195:4624741-4625031 [Pseudomonas brassicacearum]
ATTTACCGCATACAGCAAACGCAGACGTTCACTGCTTGGCATTCATCGGTCCGTGATCTGCGAGCAAAAAACGCTATTGC
CCGCCGCATTGATCGCGCCGCAGCAGGTAACCTGGGCGATGTGAAACCTGTCGGTGATGGTATTTCAGAGTTGCGTGTGG
ATGTAGGCGCTGGCTACCGGGACTATTTCACCATGCGTGGTGGATTGGTCATCGTGCTACTGGCGGGTGGTGACAAGTCT
TCACAGAGTGCTGATATCCGGCGAGCGAAGAAATTGGCAAAGGAGATTTGA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30109.49 Da
• Isoelectric Point: 9.5097

>AT183861 WP_000095577.1 NZ_CP066071:1805046-1805837 [Providencia stuartii]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT183861 NZ_CP087195:4625034-4625342 [Pseudomonas brassicacearum]
ATGAGCCAACACCTGACGACATTTGACATGGCGGCACTACTCGATAGCGACGAAGCCATCAGTGAATACCTTTCCCAAGT
GCTGGCTGATGGTGATAGCGAGGAGTTTCTCCGAGCGATCGGCTATGTCGCCAAGGCCCGAGGCATGGCACAGATCGCTA
AGGACTCTGGCATGGGACGAGAAAGCTTGTACAAGGCGTTCGCACCCGGATCAAAGCCGAGATTTGATACCGTACTCAAG
GTCATTCATGCGCTAGGCATTGATCTTCATGCGCAGCCTGGGCATGCAGCTAATCATTCACCTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A1U9VZ44