Detailed information of TA system TA183857

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 1802430..1803254
• Replicon: chromosome
• Accession: NZ_CP066065
• Organism: Schaalia meyeri strain FDAARGOS_985

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A1H1PX59
• Locus tag: I6H42_RS08000
• Protein ID: WP_074633662.1
• Coordinates: 1802430..1802948 (-)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A1H1PWU8
• Locus tag: I6H42_RS08005
• Protein ID: WP_074633661.1
• Coordinates: 1802955..1803254 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H42_RS07970	1797469..1798620	+	1152	WP_074633672.1	AAA family ATPase	-
I6H42_RS07975	1798617..1799240	+	624	WP_074633670.1	hypothetical protein	-
I6H42_RS07980	1799404..1800060	-	657	WP_074633668.1	hypothetical protein	-
I6H42_RS07985	1800148..1800897	-	750	WP_074633667.1	NADPH-dependent oxidoreductase	-
I6H42_RS07990	1800920..1801852	+	933	WP_074633665.1	alpha/beta hydrolase	-
I6H42_RS07995	1801929..1802330	+	402	WP_074633663.1	hypothetical protein	-
I6H42_RS08000	1802430..1802948	-	519	WP_074633662.1	GNAT family N-acetyltransferase	Toxin
I6H42_RS08005	1802955..1803254	-	300	WP_074633661.1	DUF1778 domain-containing protein	Antitoxin
I6H42_RS08010	1803518..1803670	-	153	WP_165603253.1	hypothetical protein	-
I6H42_RS08015	1804115..1804528	-	414	WP_165603256.1	excalibur calcium-binding domain-containing protein	-
I6H42_RS08020	1805182..1805967	+	786	WP_074633654.1	ABC transporter ATP-binding protein	-
I6H42_RS08025	1805964..1807334	+	1371	WP_074633652.1	ABC transporter permease	-
I6H42_RS08030	1807509..1807799	+	291	WP_074633651.1	hypothetical protein	-
I6H42_RS08035	1807952..1808173	+	222	WP_131800102.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-141)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-89)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19330.09 Da
• Isoelectric Point: 8.5039

>T183857 WP_074633662.1 NZ_CP066065:c1802948-1802430 [Schaalia meyeri]
MHVSVLQEPRPLAHGDDRARFQSGNDEIDDWFHRYAWQNQQARNGRVFVTVQEPETVGFYALAMGSVERGRLPAQLKPQR
RPDPCPCLLLARLAVDRRAQGRGIGAALLKDALLRAYVLSREVGFAALLVHCADQQARDFYLSQSSQFVPCPGADNHLML
PLGAIKRYVEHV

Nucleotide

• Length: 519 bp

>T183857 NZ_CP087194:4228935-4229285 [Pseudomonas sp. B21-017]
ATGGATGCTCTTTTTATCGAATTACCTGCGTTTCAGAAACACCGAGACGATTACCTGGATGACGATCTGTTTCACAGTTT
CCAGTTGGAGCTGCTGAAAAACCCCGAAGCGGGCGATCTCATTGAAGGCACGGGCGGGCTGCGAAAAATCCGCTTTTCCG
ATCAACGTCGCGGTAAAGGCAAGCGTAGCGGGCTTAGGGTGATTTATTACTGGTGGTCAGGTTTCGATCAATTCTGGCTG
TTCACCGTGTATAGCAAAAACGAGCAAGACGACCTGTCGCCTTCCCAGAAAAAACTTTTCAGACAAACGCTGGATAGAGA
AATCAACACGAGAACCCACTATGAAACGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11334.83 Da
• Isoelectric Point: 8.7015

>AT183857 WP_074633661.1 NZ_CP066065:c1803254-1802955 [Schaalia meyeri]
MSTAKTRRLDLRLTETQDTLIRRAAEQEARSVSDFVLSAAALEAQRRLTDQRVFVLNDEQYAHFEAILQAPLKDDPKLRK
LFERPSPFGTHIDTSPARP

Nucleotide

• Length: 300 bp

>AT183857 NZ_CP087194:4229275-4229589 [Pseudomonas sp. B21-017]
ATGAAACGTGACATTTTTTCCGAACTGATGGAAGGCCTCGAAGCCTTGGCCGACGAGCGCCAAGGCAAGGTCACGCTGCG
GACCCACAAGGTCAAGCTGCCGAAACTGGTACCCATCACTGCCGAGGAAGTGGTAGCCATCCGTCAACAGCTCAATCTTT
CCCGGTCGGTGTTCGCCATGTATCTGCGCACCAACACCCGAACCCTCGAAAACTGGGAACAAGGACGGGCAACACCAAAT
GCCCAAGCCACGACACTGATCCGCTTGGTTGAACGCTTTCCGCAAACAATCGAACAACTCGCAGCGCTGACCTGA

Structures

Toxin

• AlphaFold DB: A0A1H1PX59

Antitoxin

• AlphaFold DB: A0A1H1PWU8