Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1189072..1189634 Replicon chromosome
Accession NZ_CP066065
Organism Schaalia meyeri strain FDAARGOS_985

Toxin (Protein)


Gene name vapC Uniprot ID A0A1H1P0K6
Locus tag I6H42_RS05280 Protein ID WP_050694425.1
Coordinates 1189072..1189443 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H1P124
Locus tag I6H42_RS05285 Protein ID WP_050695718.1
Coordinates 1189440..1189634 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H42_RS05260 1184101..1184412 - 312 WP_070778934.1 hypothetical protein -
I6H42_RS05265 1184562..1185434 + 873 WP_074633504.1 EamA family transporter -
I6H42_RS05270 1185743..1186813 - 1071 WP_131800095.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
I6H42_RS05275 1186780..1188948 - 2169 WP_074633502.1 AAA family ATPase -
I6H42_RS05280 1189072..1189443 - 372 WP_050694425.1 type II toxin-antitoxin system VapC family toxin Toxin
I6H42_RS05285 1189440..1189634 - 195 WP_050695718.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6H42_RS05290 1190258..1192876 - 2619 WP_165603246.1 N-6 DNA methylase -
I6H42_RS05295 1192885..1193985 - 1101 WP_074633499.1 redox-regulated ATPase YchF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13991.26 Da        Isoelectric Point: 7.1683

>T183856 WP_050694425.1 NZ_CP066065:c1189443-1189072 [Schaalia meyeri]
MRILVDTNVWIDHLRTTEPVLVDLLERDQVCVHQSVITELALGNLKDRSIFLKALERLMIVRNVDDQGVRYFIQERRLWG
RGLSAVDAAILASVVVTPGMSLWTRDKRLRQAARDAGVLADLD

Download         Length: 372 bp

>T183856 NZ_CP087194:4155320-4155628 [Pseudomonas sp. B21-017]
ATGGGCCAGACTTTGACTGCTTTCGACATGGCGGCACTGCTCGACAGTGACGAAGCCATCAGCGAATACCTCTCTCAGGT
ATTGGCAGACGGCGACAACGAAGAGTTTCTTCGTGCTATCGGCTACGTGGTAAAGGCTCGCGGCATGACACAAATTGCCA
AAGATTCCGGAATGGGGCGCGAAAGCCTGTACAAGGCCTTCGCACCCGGGGCGAAACCACGTTTTGATACGGTTCTAAAG
GTCATTCATGCCTTGGGCATTGATCTCTGCGCGCAACCAGGGCACGCGGCAAATCACTCAACGCTCTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6886.81 Da        Isoelectric Point: 5.0339

>AT183856 WP_050695718.1 NZ_CP066065:c1189634-1189440 [Schaalia meyeri]
MRTTVTLDDDLLARAEELTGIRERSVLIRDAVELLVRIESGRQLAALGGSDPGAEAAPRSRARA

Download         Length: 195 bp

>AT183856 NZ_CP087194:4155024-4155317 [Pseudomonas sp. B21-017]
ATGAATTATCTTATTCAACAAACCACAATCTTCGTGGCATGGCATGCCTCAATTCGCGACTTGCGGGCGAAGGTTGCTAT
TGCTCGTCGCATTGACCGTGCCTCTACGGGTAATCTTGGCGATATCAAATCGGTGGGTGATGGTGTCTCCGAAATGCGCG
TGGACGTTGGCGCTGGCTATCGGGTCTACTTCACTTTGCGAAATGGCGTAGTCATCGTATTGCTGGCCGGTGGTGACAAG
TCCTCGCAAAACACTGATATCCGACGGGCGAAAAAATTGGCAAGGGAGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H1P0K6

Antitoxin

Source ID Structure
AlphaFold DB A0A1H1P124

References