Detailed information of TA system TA183849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1829271..1830073
• Replicon: chromosome
• Accession: NZ_CP066062
• Organism: Staphylococcus pettenkoferi strain FDAARGOS_1071

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I6I28_RS08795
• Protein ID: WP_103370338.1
• Coordinates: 1829271..1829732 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I6I28_RS08800
• Protein ID: WP_002439260.1
• Coordinates: 1829744..1830073 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I28_RS08770	1824569..1825465	+	897	WP_103370334.1	TIGR01777 family oxidoreductase	-
I6I28_RS08775	1825596..1826432	-	837	WP_103370335.1	hypothetical protein	-
I6I28_RS08780	1826745..1827782	-	1038	WP_103370336.1	site-specific integrase	-
I6I28_RS08785	1827897..1828499	-	603	WP_088606582.1	hypothetical protein	-
I6I28_RS08790	1828594..1829253	-	660	WP_103370337.1	hypothetical protein	-
I6I28_RS08795	1829271..1829732	-	462	WP_103370338.1	ImmA/IrrE family metallo-endopeptidase	Toxin
I6I28_RS08800	1829744..1830073	-	330	WP_002439260.1	helix-turn-helix domain-containing protein	Antitoxin
I6I28_RS08805	1830267..1830506	+	240	WP_103370339.1	helix-turn-helix domain-containing protein	-
I6I28_RS08810	1830520..1831287	+	768	WP_103370340.1	phage antirepressor	-
I6I28_RS08815	1831385..1831678	-	294	WP_103370342.1	hypothetical protein	-
I6I28_RS08820	1831745..1831990	+	246	WP_103370341.1	DUF2829 domain-containing protein	-
I6I28_RS08825	1832108..1832332	-	225	WP_049408449.1	hypothetical protein	-
I6I28_RS08830	1832388..1832699	+	312	WP_103370358.1	DUF771 domain-containing protein	-
I6I28_RS08835	1832961..1833185	+	225	WP_088606589.1	DUF2483 family protein	-
I6I28_RS08840	1833178..1833849	+	672	WP_103370356.1	ERF family protein	-
I6I28_RS08845	1833849..1834271	+	423	WP_103370355.1	single-stranded DNA-binding protein	-
I6I28_RS08850	1834282..1834950	+	669	WP_103370354.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	clpP	1826745..1872068	45323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (25-119)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18288.04 Da
• Isoelectric Point: 6.4082

>T183849 WP_103370338.1 NZ_CP066062:c1829732-1829271 [Staphylococcus pettenkoferi]
MGLYEKMLIEHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSEIRKAEVLYEELAHHKLTYGNILDQSKWINRKFENYAK
RHGYEAALPLRIIVEAHHYGVSNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYIEI

Nucleotide

• Length: 462 bp

>T183849 NZ_CP087193:2228814-2229002 [Pseudomonas sp. B21-019]
ATGACGACCCAGATCAAGGGCTATCCGTTCAAGGTGCCGATTGCCGGGGCCAAGCCCAGCGCGGTGCTGGCCGATAAAGT
CAAAAGAGTCGACTGGGTAGCGCGCAAGGTACAGTACAAAGGCCAATTAACCGCCGCAGAACTGGAGCAAATCCAGCGCG
TGGTTGCGGCGTTGATTGGTCCTCCTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12735.32 Da
• Isoelectric Point: 5.7917

>AT183849 WP_002439260.1 NZ_CP066062:c1830073-1829744 [Staphylococcus pettenkoferi]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Nucleotide

• Length: 330 bp

>AT183849 NZ_CP087193:2228502-2228675 [Pseudomonas sp. B21-019]
GTGTTCGAGCTTGACCTGGAGGTCGACGTGCGGGTTGAAGGCAACCGGATGATCATCGAACCGGTGCGCGAGTCCTTGGA
CCTGGCCAGGCTGTTGGCCAAGGTGACCCCGGAGAACCGCCACGAAGCGGTTGACTGGGGCCACCGGTTGGCAAGGAGGT
CTGGTAATAGCTAA