183847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 495542..496050 Replicon chromosome
Accession NZ_CP066062
Organism Staphylococcus pettenkoferi strain FDAARGOS_1071

Toxin (Protein)


Gene name mazF Uniprot ID A0A2K4FCJ6
Locus tag I6I28_RS02490 Protein ID WP_002471121.1
Coordinates 495542..495880 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K4FCQ5
Locus tag I6I28_RS02495 Protein ID WP_002471108.1
Coordinates 495877..496050 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I28_RS02470 492446..493216 - 771 WP_049405752.1 RNA polymerase sigma factor SigB -
I6I28_RS02475 493191..493670 - 480 WP_169931219.1 anti-sigma B factor RsbW -
I6I28_RS02480 493672..493998 - 327 WP_103369939.1 anti-sigma factor antagonist -
I6I28_RS02485 494077..495078 - 1002 WP_049405748.1 PP2C family protein-serine/threonine phosphatase -
I6I28_RS02490 495542..495880 - 339 WP_002471121.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6I28_RS02495 495877..496050 - 174 WP_002471108.1 hypothetical protein Antitoxin
I6I28_RS02500 496140..497288 - 1149 WP_049405746.1 alanine racemase -
I6I28_RS02505 497360..497710 - 351 WP_049405745.1 holo-ACP synthase -
I6I28_RS02510 497978..498550 - 573 WP_103369938.1 PH domain-containing protein -
I6I28_RS02515 498537..500039 - 1503 WP_103369937.1 PH domain-containing protein -
I6I28_RS02520 500032..500511 - 480 WP_049405739.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12613.74 Da        Isoelectric Point: 10.3172

>T183847 WP_002471121.1 NZ_CP066062:c495880-495542 [Staphylococcus pettenkoferi]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSDSKMEEVNKAIRISLGLH

Download         Length: 339 bp

>T183847 NZ_CP087193:c1077509-1077255 [Pseudomonas sp. B21-019]
ATGAATATCGAGTTCACTCCTGAAGGCTGGGACGACTATTTGTGGTTTCAGCAAAACGATAAGGCCGGGCTCAAACGAAT
CAACCTACTGATCAAGGCGATCCTGCGTGAGCCCTTCGAAGGTTTGGGGAAACCTGAACCGCTCAAACACAACCTGAGCG
GCCTCTGGTCACGCCGAATCACCTCCGAGCATCGTCTGGTTTATGCAATCGAGAATGGTGAGGTGCGCATCGTGCTTTGC
AGGTATCACTACTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6485.05 Da        Isoelectric Point: 4.0121

>AT183847 WP_002471108.1 NZ_CP066062:c496050-495877 [Staphylococcus pettenkoferi]
MSGFNQSRNHSIEQLLKEGYSQMADLNLSLATEAFPFECEACDCNESYISSNFNNER

Download         Length: 174 bp

>AT183847 NZ_CP087193:c1077760-1077506 [Pseudomonas sp. B21-019]
ATGCAAACCATCAACTACACCACCGCACGTGCACATCTGGCCGAAACCATGGATCGGGTCAACGAAGACCGTGCCCCATT
GCTGGTTACCCGCCAGAAAGGCGAACCTGTGGTGATGATGTCTCTGGCGGAGTACAACGCTCTCGAAGAGACAGCCTATC
TGCTCCGTTCTCCAGCCAATGCCGAGCGGCTGATCAAATCAATCGGTAACCTGCGAGCAGGGAAGACCAAAGTCAGGCAA
CTTATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4FCJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4FCQ5

References