183846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2331863..2332434 Replicon chromosome
Accession NZ_CP066060
Organism Actinomyces oris strain FDAARGOS_1051

Toxin (Protein)


Gene name vapC Uniprot ID A0A1Q8WPJ8
Locus tag I6I08_RS09815 Protein ID WP_075379132.1
Coordinates 2332057..2332434 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F2UXK9
Locus tag I6I08_RS09810 Protein ID WP_003787711.1
Coordinates 2331863..2332060 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I08_RS09800 2327821..2329128 - 1308 WP_075379134.1 phosphoribosylamine--glycine ligase -
I6I08_RS09805 2329293..2331605 + 2313 WP_141407241.1 TerD family protein -
I6I08_RS09810 2331863..2332060 + 198 WP_003787711.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6I08_RS09815 2332057..2332434 + 378 WP_075379132.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I08_RS09820 2332516..2333109 + 594 WP_075379131.1 hypothetical protein -
I6I08_RS09825 2333097..2334356 - 1260 WP_141407240.1 hypothetical protein -
I6I08_RS09830 2334386..2335720 - 1335 WP_075379129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13699.69 Da        Isoelectric Point: 6.2115

>T183846 WP_075379132.1 NZ_CP066060:2332057-2332434 [Actinomyces oris]
VILVDTSVWIDHFHHSDPVLVSLLHEDEIGSHPLVAEELAMGSLRARDDVLKHLAHLRQFPVLSHDELLTLVAAPALWGR
GLSPVDAHLLGSVTLVPGARLWTRDKRLLRAAEERGVSFTEGTAG

Download         Length: 378 bp

>T183846 NZ_CP087192:c1807684-1807109 [Pseudomonas sp. B21-021]
GTGAGGCATTCCTCTTTCACCGCTTTATATGACGCATGCGTCTTGTACCCCGCCCCCTTGAGAGACTTCCTCATGTGGCT
TGCGCTCTCAGGACGATTTCGGGCGCGATGGACCCAGGAGATTCACTGCGAATGGAAACGCAATCTGCTGAAGAACCGCC
GTGACCTGACGATGGAACAGCTGGATCGTACGTCCGGCCTGATGGATCAAGCGATACCCGACGCCTGTGTCCATGACTAT
GAAGACCTGATTGCCGGACTCAGCTTGCCCGACTGCGATGATCGTCATGTTCTGGCAGCGGCCATCCGTTGCGGCGCAAG
CGTGATAGTGACGTTCAATCAGAAAGACTTTCCCTGCAAAGCGCTGGAGCCTTTCGGCATCGAAGCGCAGCATCCGGACG
AGTTCGTCGACAACCTCTTGGGGCTTGATCCGGCAGCAGTGGTTGCAGCGGCCCAAAAACAGCGTCGGCAGCTGAAAATG
CCTGCCATGGACGTCGAACCCTTTCTTGATCTACTGCAACGACAAGGCCTGATTAAATCGGTCCGGGCACTCAGCGGCTA
TCACGCGATTCTTTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6949.80 Da        Isoelectric Point: 11.5457

>AT183846 WP_003787711.1 NZ_CP066060:2331863-2332060 [Actinomyces oris]
VRTTVTLSDDLIANAQELTGITERTELLRAGLETLVRVESARRLAALGGSDRTASAAPRRRSASQ

Download         Length: 198 bp

>AT183846 NZ_CP087192:c1808148-1807681 [Pseudomonas sp. B21-021]
ATGTCGACCGTTATTCATCCCTCCATCAGCCTCCCCGTAGAACGCGAAGTAAAAGCCGCCATTGAAGGGCAGCGTGCCCT
GGCGGCTTACCTCGCGACCCATTTCGAGACTCAGCACATCCAGATTTTCGACGAGCAGAACGAAGCTCATCGCGTCGAAC
TGCCCACCTCGGCCCTGCGCTTGCTGATCGACATTCTGGCGGAACTGGCAGCCGGCAACGCGGTGCAGGTCGTACCGGTG
CATGCCGAATTGACGACCCAGGAAGCCGCCGACCTCCTCAACGTCTCACGTCCACACCTCATAAAACTGCTGGAAAGCGG
CGAGTTGTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGAATATAAGACCCGGCGCACCA
CCGCCAGCGAGCAGGCAATGGCGCTTCTCGCAGAGCAAGCTCAGGCGTTAAGGACAGGATACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8WPJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1VW34

References