Detailed information of TA system TA183845

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 2215903..2216408
• Replicon: chromosome
• Accession: NZ_CP066060
• Organism: Actinomyces oris strain FDAARGOS_1051

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6I08_RS09370
• Protein ID: WP_141407291.1
• Coordinates: 2215903..2216157 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q8VK28
• Locus tag: I6I08_RS09375
• Protein ID: WP_075410880.1
• Coordinates: 2216157..2216408 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I08_RS09355	2211208..2212428	+	1221	WP_141407294.1	homoserine O-acetyltransferase	-
I6I08_RS09360	2212703..2215438	+	2736	WP_141407293.1	exo-alpha-sialidase	-
I6I08_RS09365	2215734..2215886	-	153	Protein_1829	type II toxin-antitoxin system Phd/YefM family antitoxin	-
I6I08_RS09370	2215903..2216157	-	255	WP_141407291.1	Txe/YoeB family addiction module toxin	Toxin
I6I08_RS09375	2216157..2216408	-	252	WP_075410880.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6I08_RS09380	2216583..2216906	+	324	WP_141407322.1	HigA family addiction module antidote protein	-
I6I08_RS09385	2217058..2218068	-	1011	WP_141407290.1	hypothetical protein	-
I6I08_RS09390	2218203..2219807	-	1605	WP_141407289.1	Na+/H+ antiporter	-
I6I08_RS09395	2219998..2221242	-	1245	WP_141407288.1	type II toxin-antitoxin system HipA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9908.33 Da
• Isoelectric Point: 9.3345

>T183845 WP_141407291.1 NZ_CP066060:c2216157-2215903 [Actinomyces oris]
MRLVWDPSAWEDYTYWQKADRRILKRVNTLIDAALRDPFGGIGKPEQLKYGASGAWSRRITDEHRLVYLIAGDDLVILQV
RYHY

Nucleotide

• Length: 255 bp

>T183845 NZ_CP087192:203827-204108 [Pseudomonas sp. B21-021]
ATGACCTATAAGCTCGAATTTCTGCCTTCCGCTCACAAAGAGTGGAACAAACTGGGTCATACGTTGCGTGATCAATTTAA
AAAGAAGTTGGCTGAGCGTCTTGAGCGTCCCCGTATTCCGGCTGACTCCCTCCACGGCATGCCTGATTGCTACAAGATCA
AACTCAAAGCGTCCGGTTATCGACTGGTTTACCAAGTGATCGAAGAGCGAGTGGTTGTCTCGGTAGTCGCCGTGGGTAAG
CGCGAGCGAGGCGACGTCTACGAAAACGCGAAAAGACGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9464.50 Da
• Isoelectric Point: 4.8500

>AT183845 WP_075410880.1 NZ_CP066060:c2216408-2216157 [Actinomyces oris]
MSISASEARKTLYPLIERVNADHDAVEIVSRKGSAVLMPADEYAAWQETAYLFRSPENARRLLDAYDRARAGHTEMHDLD
RED

Nucleotide

• Length: 252 bp

>AT183845 NZ_CP087192:203592-203837 [Pseudomonas sp. B21-021]
ATGCAAAGTGTTCTGGCCGATATGGCTGTCAGTGTTTCTGAACTGAAGAAAAACCCCTCCGCAGTGCTAAACGGCGCGCA
CGGAGGAGCAGTTGCTGTCCTGAATCACAACCGGGTCATGGGCTACATGGTGCCGGCTGACGTTTACGAAGCCATGATGG
AGCGGCTCGATGATCTCGAGTTGGCAGAAATCGTTCGTTCTCGCAGTCACGAGACTCCCATACCGGTAAGCCTGGATGAC
CTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q8VK28