Detailed information of TA system TA183834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 1908983..1909581
• Replicon: chromosome
• Accession: NZ_CP066050
• Organism: Brucella anthropi strain FDAARGOS_1039

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: I6H96_RS09430
• Protein ID: WP_158304319.1
• Coordinates: 1908983..1909267 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: A0A256GNU9
• Locus tag: I6H96_RS09435
• Protein ID: WP_041545288.1
• Coordinates: 1909267..1909581 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H96_RS09390	1904192..1905085	-	894	WP_012090883.1	MurR/RpiR family transcriptional regulator	-
I6H96_RS09395	1905242..1905457	+	216	WP_094513475.1	hypothetical protein	-
I6H96_RS09400	1905471..1905725	+	255	WP_041544962.1	type II toxin-antitoxin system HicA family toxin	-
I6H96_RS09405	1905893..1906054	+	162	WP_140986072.1	toxin-antitoxin system HicB family antitoxin	-
I6H96_RS09410	1906209..1906635	-	427	Protein_1836	type IV secretory system conjugative DNA transfer family protein	-
I6H96_RS09415	1906937..1907191	-	255	WP_012090879.1	toxin-antitoxin system HicB family antitoxin	-
I6H96_RS09420	1907188..1907463	-	276	Protein_1838	PIN domain-containing protein	-
I6H96_RS09425	1907623..1908804	-	1182	WP_012090877.1	Fic family protein	-
I6H96_RS09430	1908983..1909267	+	285	WP_158304319.1	hypothetical protein	Toxin
I6H96_RS09435	1909267..1909581	+	315	WP_041545288.1	BrnA antitoxin family protein	Antitoxin
I6H96_RS09440	1910440..1910586	-	147	WP_158304318.1	hypothetical protein	-
I6H96_RS09445	1910691..1914149	-	3459	WP_012090874.1	chromosome segregation protein SMC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1838728..1914273	75545

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (28-102)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10840.76 Da
• Isoelectric Point: 10.8134

>T183834 WP_158304319.1 NZ_CP066050:1908983-1909267 [Brucella anthropi]
MSQSVEFMLLKTQWYLSRNWIRAKWKTGSNSIETQHLHLEFFLSAKVFPTKADRLMAIGEFNGQIIIVVVFKPIGSEALS
VISMRPASQKERKL

Nucleotide

• Length: 285 bp

>T183834 NZ_CP087189:c757948-757658 [Pseudomonas protegens]
ATGCGCCCCCCAGTGACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCGTGCTGATCCGCGCCGCACTCAACGACATCGCCCGTGCCCGCGGCATGACCCAGG
TCGCCCGTGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCCCTCGGCAGCCAGGGCAACCCGGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCCCTGGGGTTGAAGATCAACGTCAGCAACGCCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11605.44 Da
• Isoelectric Point: 10.3131

>AT183834 WP_041545288.1 NZ_CP066050:1909267-1909581 [Brucella anthropi]
MGIKFSSKRPLTQEEEAAIQKMIASDPDAPEATDEQLAKAKPFKEALPEMAAKMEKAIRGRPRIDDPKTPVTIRLDQDVV
QRFKATGKGWQSRMNEALRKAVGL

Nucleotide

• Length: 315 bp

>AT183834 NZ_CP087189:c758254-757952 [Pseudomonas protegens]
ATGTTCGTTTTCGAGCAGACTCCTGAGTTCAGCCGCTGGCTGCTGAACCTGAAGGACCCGCAAGGGAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCACAGCTGGGCCGTTTTGGCGACTGCGAACCTGTGGGCGAAGGCGTCCACGAGATACGCATCC
ACCGCGGCCCGGGTTACCTGGTGTACTTCTCGCACCGCGGCAAAGTGATCTACCTGCTGTTGATCGGCGGCGACAAGGCC
ACCCAGAACCGCGATATCCAACGGGCCAGGCAACTGGCCTGCGACCTCAAGAGCGAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A256GNU9