Detailed information of TA system TA183831

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 30139..30664
• Replicon: plasmid unnamed
• Accession: NZ_CP066048
• Organism: Salmonella enterica strain FDAARGOS_1066

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: I6I23_RS22810
• Protein ID: WP_001159863.1
• Coordinates: 30359..30664 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: I6I23_RS22805
• Protein ID: WP_000813641.1
• Coordinates: 30139..30357 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I23_RS22775	25753..26139	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
I6I23_RS22780	26192..26353	+	162	WP_015059604.1	hypothetical protein	-
I6I23_RS22785	26680..27669	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
I6I23_RS22790	28163..28458	-	296	Protein_42	cytoplasmic protein	-
I6I23_RS22795	28470..28898	+	429	Protein_43	hypothetical protein	-
I6I23_RS22800	28942..29463	-	522	WP_077681952.1	hypothetical protein	-
I6I23_RS22805	30139..30357	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
I6I23_RS22810	30359..30664	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
I6I23_RS22815	30666..30956	+	291	WP_001266176.1	hypothetical protein	-
I6I23_RS22820	30953..31474	+	522	WP_000198608.1	hypothetical protein	-
I6I23_RS22825	31509..32291	+	783	WP_000082169.1	site-specific integrase	-
I6I23_RS22830	32300..33013	+	714	WP_000545756.1	EAL domain-containing protein	-
I6I23_RS22835	33017..33526	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
I6I23_RS22840	33520..34005	+	486	WP_000905606.1	membrane protein	-
I6I23_RS22845	34282..34569	-	288	WP_071530243.1	hypothetical protein	-
I6I23_RS22850	34725..35285	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59372	59372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T183831 WP_001159863.1 NZ_CP066048:30359-30664 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T183831 NZ_CP087188:c2266491-2266309 [Pseudomonas laurylsulfatiphila]
ATGAAGTACAGCGAGTTCAGACGATGGTTGAAGGCCCGAGGGGTGATCTTCGAAGCAGGCAAAGGCACTAGCCACTTCAA
GATCTACTACAACGGCAAACAAACGGTCTTTGCGGACCACGGCGCTAAGGAAATGAAAGAGCCAACCCGCAAAGGAATCA
TCAAACAGCTGGGGCTTGAATGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT183831 WP_000813641.1 NZ_CP066048:30139-30357 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT183831 NZ_CP087188:c2266259-2265834 [Pseudomonas laurylsulfatiphila]
ATGTACGACTATCCCGTGATCATTCACGAGGACGAAAACCCTGGGGTTGCGGTGACTGCGCCGGATCTACCAGAGTTCAA
CAGTGCCGGGGACGATGTCGCCGACGCGCTGCGTGAATCCGTGGACGGCATTGAAACCGCCCTCTCCATCTACGTCGACC
AGCGCCGAGTCATTCCGCCTGCTTCCCAACCAGAGCCGGGCCAGCATGTGGTCCGGCTGCCTGCAGTGACCGTGGCCAAG
ATCGTCCTGTGGAACGAGATGATGGCGCGCGATATGCGCAAGGCCGATTTGTGCCGCCTTCTCGGACTGGCTCAGACCCA
GGGAGATCGCCTGGTCGACTTCCTGCACACCTCTAAGATGGAGGCAATCGAGAAGGCTTTGGCTGCCCTGGGCAAACGCC
TGGTGGTGTCTGTCGAAGCAGCCTGA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6