Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2288135..2288932 Replicon chromosome
Accession NZ_CP066042
Organism Staphylococcus saccharolyticus strain FDAARGOS_1074

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag I6I31_RS11085 Protein ID WP_115313055.1
Coordinates 2288135..2288308 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag I6I31_RS11090 Protein ID WP_115313054.1
Coordinates 2288333..2288932 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I31_RS11065 2283650..2284759 - 1110 Protein_2163 GAF domain-containing sensor histidine kinase -
I6I31_RS11070 2284918..2285742 + 825 WP_115313058.1 RluA family pseudouridine synthase -
I6I31_RS11075 2285837..2287222 - 1386 WP_115313057.1 class II fumarate hydratase -
I6I31_RS11080 2287593..2287997 - 405 WP_115313056.1 hypothetical protein -
I6I31_RS11085 2288135..2288308 - 174 WP_115313055.1 hypothetical protein Toxin
I6I31_RS11090 2288333..2288932 - 600 WP_115313054.1 glucosamine-6-phosphate isomerase Antitoxin
I6I31_RS11095 2289107..2289577 - 471 WP_115313053.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I6I31_RS11100 2289574..2290703 - 1130 Protein_2170 tRNA epoxyqueuosine(34) reductase QueG -
I6I31_RS11105 2290829..2291557 - 729 Protein_2171 amino acid ABC transporter ATP-binding protein -
I6I31_RS11110 2291550..2292595 - 1046 Protein_2172 ABC transporter substrate-binding protein/permease -
I6I31_RS11115 2292740..2293798 - 1059 WP_115313052.1 PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6652.19 Da        Isoelectric Point: 4.3747

>T183829 WP_115313055.1 NZ_CP066042:c2288308-2288135 [Staphylococcus saccharolyticus]
MSNKKNSKLNYHEEENAMVTDLDDLKELGKEMEHISEKNDEDKVNQSHDEICSDKTN

Download         Length: 174 bp

>T183829 NZ_CP087188:1058510-1058854 [Pseudomonas laurylsulfatiphila]
ATGCGAACCGTATTCTTCGAAACCACATCTTTCACTGCTACCGTGGGTAATTATCTGACGGACGATGAGTATCGTGCGTT
GCAGTCGCACATGCAGTTGAACCCGCAAGCGGGTGATGTCATGCCTCGAACAGGCGGTTTCCGAAAGCTGCGTTGGGCAG
ATGGACGTCGCGGTAAAGGTAGGCGAGGTGGCTTGCGGGTTATCTATTATTGGCTTATGAATGATGGCCAGTTCTGGATG
TTTGCAATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGACCAAGAGAAGGTGCTCAAGAAAGCCATAGAAACAGA
GTTGAAAAAACGAGGTACCCCATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22746.65 Da        Isoelectric Point: 4.8725

>AT183829 WP_115313054.1 NZ_CP066042:c2288932-2288333 [Staphylococcus saccharolyticus]
MAMNFKVFDNNDRVAEYAADIIRKQFNNNPTTIAGFHLDKEHAPVLDELKKNVDCHAVDFSQINILDYDNNRSYYETLGV
PEGQVYSISYDQDAIGFISDKMKTKENKGKLILQVLSIDENGKLDVNVRQGLMEAREIFLIITGSQKRDVVEKLYRENGK
SSYEPADLKAHRMVNVILDKESAEGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT183829 NZ_CP087188:1058851-1059165 [Pseudomonas laurylsulfatiphila]
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGCAAGATTACATT
GCGCAATACGGTTGTGGAGGACATCCCTGCACCAGAGGTGGGGGCGCAAGAGATCGTTGCGCTACGGGAAAAGTTACACA
TGTCCCAGGCTGTTTTTGCCAAGCGAATTCGAACCAGCCCCAGCACCCTGAGAAACTGGGAGCAGGAAAAGTCGAAGCCC
AATGCTCAGGCCGCCTTGCTGATCAGGTTGGTGGAGAAATTCCCGGATATGGTGGATCGACTTGCAGTCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References