Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 77426..77955 Replicon chromosome
Accession NZ_CP066042
Organism Staphylococcus saccharolyticus strain FDAARGOS_1074

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I6I31_RS00410 Protein ID WP_115312959.1
Coordinates 77426..77788 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I6I31_RS00415 Protein ID WP_115312958.1
Coordinates 77785..77955 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I31_RS00390 74419..75189 - 771 WP_115312963.1 RNA polymerase sigma factor SigB -
I6I31_RS00395 75164..75643 - 480 WP_115312962.1 anti-sigma B factor RsbW -
I6I31_RS00400 75645..75971 - 327 WP_115312961.1 anti-sigma factor antagonist -
I6I31_RS00405 76073..77074 - 1002 WP_115312960.1 PP2C family protein-serine/threonine phosphatase -
I6I31_RS00410 77426..77788 - 363 WP_115312959.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6I31_RS00415 77785..77955 - 171 WP_115312958.1 antitoxin MazE Antitoxin
I6I31_RS00420 78042..79190 - 1149 WP_115312957.1 alanine racemase -
I6I31_RS00425 79250..79612 - 363 WP_115312956.1 holo-ACP synthase -
I6I31_RS00430 79723..80175 - 453 WP_115312955.1 PH domain-containing protein -
I6I31_RS00435 80162..81663 - 1502 Protein_81 PH domain-containing protein -
I6I31_RS00440 81656..82168 - 513 Protein_82 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13542.69 Da        Isoelectric Point: 10.0250

>T183827 WP_115312959.1 NZ_CP066042:c77788-77426 [Staphylococcus saccharolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQKS

Download         Length: 363 bp

>T183827 NZ_CP087188:175025-175306 [Pseudomonas laurylsulfatiphila]
ATGACTTATAAGCTCGAATTTCTCCCGTCTGCACGCAAAGAATGGGACAAGCTGGGGCACACAGTGCGTGAGCAATTCAA
AAAGAAACTGTCAGAGCGGCTTGAGGTGCCTCGAATCCAGTCTGACGCGCTGCATGGCATGCCTGACTGCTACAAGATCA
AGCTGAGGTCATCGGGATATCGACTCGTCTACGAGGTGATAGATGAGCGCATCGTTGTTTCTGTCGTTGCAGTAGGAAAG
CGCGAACGCAGTGAGGTGTATGAGCGCGCCAGGAAACGTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6257.82 Da        Isoelectric Point: 3.6326

>AT183827 WP_115312958.1 NZ_CP066042:c77955-77785 [Staphylococcus saccharolyticus]
MLSFNQTRTNSLEQSLKEGYSQMADLNLSLATEAFPIECEACDCNETYLTSNSQSE

Download         Length: 171 bp

>AT183827 NZ_CP087188:174790-175035 [Pseudomonas laurylsulfatiphila]
ATGCAAAATGTTTTGGCCGATATGGCTGTCAGCGTGTCTGAACTAAAGAAAAACCCCTCTGCCGTTTTGAATGGCGCCCA
TGGAGGGCCTGTCGCGGTGCTCAATCACAATCGCGTCATGGGCTACATGGTTCCTGCCGATGTGTTCGAAGCCATGATGG
AGCGCCTTGATGATTTGGAGTTGGCGGAACTCGTGCGTTCTCGTCGTCATGAAACGCCGATCCCGGTAACGCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References