Detailed information of TA system TA183824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 539326..539950
• Replicon: chromosome
• Accession: NZ_CP066041
• Organism: Streptococcus oralis strain FDAARGOS_1075

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G0I8P0
• Locus tag: I6I32_RS02690
• Protein ID: WP_001131503.1
• Coordinates: 539762..539950 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I6I32_RS02685
• Protein ID: WP_198464863.1
• Coordinates: 539326..539703 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I32_RS02655	534437..536236	+	1800	WP_198464859.1	N-acetylmuramoyl-L-alanine amidase	-
I6I32_RS02660	536265..536582	-	318	WP_198464860.1	hypothetical protein	-
I6I32_RS02665	536809..537708	-	900	WP_198464861.1	hypothetical protein	-
I6I32_RS02670	538262..538546	-	285	WP_198464862.1	hypothetical protein	-
I6I32_RS02675	538588..538961	-	374	Protein_528	DUF86 domain-containing protein	-
I6I32_RS02680	538942..539256	-	315	WP_125833854.1	nucleotidyltransferase domain-containing protein	-
I6I32_RS02685	539326..539703	-	378	WP_198464863.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6I32_RS02690	539762..539950	-	189	WP_001131503.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6I32_RS02700	540383..541168	-	786	WP_198464864.1	ABC transporter permease	-
I6I32_RS02705	541170..541988	-	819	WP_198464865.1	ABC-2 family transporter protein	-
I6I32_RS02710	541990..542982	-	993	WP_061426957.1	ATP-binding cassette domain-containing protein	-
I6I32_RS02715	543356..544288	-	933	WP_198464866.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7038.21 Da
• Isoelectric Point: 9.8162

>T183824 WP_001131503.1 NZ_CP066041:c539950-539762 [Streptococcus oralis]
MPLTGKEMVKLALENGWVEVRQRGSHHHFKKEGFSYLVTIPVHGNEDLGKGLERKILKDLGL

Nucleotide

• Length: 189 bp

>T183824 NZ_CP087187:3291210-3291431 [Pseudomonas atacamensis]
ATCGACTACGTAGAACAACGCAACACTGTCGCTTCAGTTGCACTGCACCAAAAGATCAGCGCCGCAGCGCGAAGGCTTTC
CTGGATACCGCATGGTTTCCGCTCCGGCCGAATACCGGGCACTCGCGAAATGGTCATTAACTCGAATTATTTGCTGGTCT
ATCGGGTGACAGAACACATCAAAATTCTGACCGTGTTGCACGCCCGTAAAAAATATCCATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14088.24 Da
• Isoelectric Point: 4.9572

>AT183824 WP_198464863.1 NZ_CP066041:c539703-539326 [Streptococcus oralis]
MLKTYPAIFHKEGTGYWVEFPEFGGGTEGKNINEAMKNAREMLENILASYIDEGMALPTPSDILKIEVSDGFVSMIQVDP
APFVRSNKAIRKNVTVPEWLVRLADREKINYSEVLAQALEKKLQV

Nucleotide

• Length: 378 bp

>AT183824 NZ_CP087187:3290978-3291172 [Pseudomonas atacamensis]
ATGAGCGCTGAACTTTCACTTATCGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGGATTACGATCTTTGGTATCGCGC
CAAGGTACAAGCCGCACTTGATGATCCACGTCCGCCTATCCCCCACGATGAGGCAATGGTGCTGCTAGGTCAGATGCTGG
AAGAGAGACGCAAGAATCGACGCGCTGCCGGTTAG

Structures

Toxin

• AlphaFold DB: G0I8P0