Detailed information of TA system TA183823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 632927..633461
• Replicon: chromosome
• Accession: NZ_CP066040
• Organism: Burkholderia ambifaria strain FDAARGOS_1027

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q0B2J5
• Locus tag: I6H84_RS31110
• Protein ID: WP_011660961.1
• Coordinates: 633162..633461 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q0B2J6
• Locus tag: I6H84_RS31105
• Protein ID: WP_011660960.1
• Coordinates: 632927..633172 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H84_RS31080	628191..628916	-	726	WP_006750591.1	pirin family protein	-
I6H84_RS31085	629044..629928	+	885	WP_011660956.1	LysR family transcriptional regulator	-
I6H84_RS31090	630131..631156	+	1026	WP_011660957.1	DUF1311 domain-containing protein	-
I6H84_RS31095	631398..631856	+	459	WP_011660958.1	MEKHLA domain-containing protein	-
I6H84_RS31100	632125..632607	+	483	WP_011660959.1	hypothetical protein	-
I6H84_RS31105	632927..633172	+	246	WP_011660960.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
I6H84_RS31110	633162..633461	+	300	WP_011660961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6H84_RS31115	633972..634385	+	414	WP_011660963.1	DoxX family protein	-
I6H84_RS31120	634547..635491	+	945	WP_041491790.1	SDR family oxidoreductase	-
I6H84_RS31125	635932..637281	+	1350	WP_041491791.1	reverse transcriptase family protein	-
I6H84_RS31130	637650..637979	+	330	WP_006750598.1	H-NS histone family protein	-
I6H84_RS31135	638172..638426	+	255	Protein_519	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11821.36 Da
• Isoelectric Point: 6.4862

>T183823 WP_011660961.1 NZ_CP066040:633162-633461 [Burkholderia ambifaria]
MPIEARLVRLTPLAEADLEDIWTYTFERWSLEQAEHYVGELASAFERLARREWRGRPSRAGNGYWRYMVGSHVVFYRETA
DSLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T183823 NZ_CP087187:3115522-3115812 [Pseudomonas atacamensis]
ATGGCTGAATACCGACTTACCCCCGCCGCCGTAGCGGATCTTGAGGCTATCTGGACCTATACAGCTCAACAATGGGGTTT
GGATCAGGCCAATCGCTACATCGACATCCTGACTGCGTCTTTCGAGCAGTTGGCTGATCGTCCCAAAACAGCACCCGCAT
GCGACGCGATCCGCCCCGGTTACCGACGCTGCAGCGTGGAGAGTCACGTGATTTATTTTCGAATCACCGCCTATGGGATC
GCGATAATCAGAATCTTGCATGACCGGATGGAAGCGCAGCGTAATCTCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8806.80 Da
• Isoelectric Point: 5.6726

>AT183823 WP_011660960.1 NZ_CP066040:632927-633172 [Burkholderia ambifaria]
MARNTSISLGDHLAQFVDTQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGEPTAFDSQAFLERMRKKHA
D

Nucleotide

• Length: 246 bp

>AT183823 NZ_CP087187:3115284-3115529 [Pseudomonas atacamensis]
ATGGCTACCGTACGAAAAACCATAACCGTGACTGACCAGCAAGACCATTGGATCAAAGCTCAAATAGAAGCGGGACATTA
CACCAACGACAGCGAATATATCCGCGATTTGATCCGTCGAGAGCAAGAGCGAAACGCTGAACTGGAAACCGTCCGCGCAG
CCCTTCGAGAAGGAGAATCCAGTGGTGCCCCCCGGCCATTCGATGCTGATGCTTTCAAAAAGAGAATGTTGAGGGCGCAT
GGCTGA

Structures

Toxin

• AlphaFold DB: Q0B2J5

Antitoxin

• AlphaFold DB: Q0B2J6