183815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 5152136..5152973 Replicon chromosome
Accession NZ_CP066032
Organism Escherichia coli strain FDAARGOS_1059

Toxin (Protein)


Gene name itaT Uniprot ID A0A0F5GET7
Locus tag I6I16_RS25560 Protein ID WP_000227783.1
Coordinates 5152431..5152973 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag I6I16_RS25555 Protein ID WP_001297137.1
Coordinates 5152136..5152447 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I16_RS25530 5147156..5148103 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
I6I16_RS25535 5148125..5150116 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
I6I16_RS25540 5150106..5150720 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
I6I16_RS25545 5150720..5151049 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
I6I16_RS25550 5151061..5151951 + 891 WP_000971336.1 heme o synthase -
I6I16_RS25555 5152136..5152447 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
I6I16_RS25560 5152431..5152973 + 543 WP_000227783.1 GNAT family N-acetyltransferase Toxin
I6I16_RS25565 5153029..5153964 - 936 WP_001297127.1 sel1 repeat family protein -
I6I16_RS25570 5154372..5155736 + 1365 WP_001000978.1 MFS transporter -
I6I16_RS25575 5155864..5156355 - 492 WP_001138904.1 nucleotide binding protein YajQ -
I6I16_RS25580 5156523..5157434 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19776.96 Da        Isoelectric Point: 8.0330

>T183815 WP_000227783.1 NZ_CP066032:5152431-5152973 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKQGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T183815 NZ_CP087186:5088344-5088622 [Pseudomonas siliginis]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGTGGCTTCTATGAAACAGGTACGACTCGTGGAATTCGTGCCGACCATGC
AAAACGGCTTTCGCGCATGTTGCAGTTCATGGATCGAGCGACGCTTCCCGCAGACCTGGACTTGCCCGGCTGGCGCCTGC
ATCCGTTGAAAGGTGAGCTGAGCGAATATTGGTCGCTCAGCGTTTCAGGCAACTGGCGAGTGATCTTTCGTTTTGTCGGT
TCGGATATCGAATTGGTCGATTATCTGGACTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT183815 WP_001297137.1 NZ_CP066032:5152136-5152447 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT183815 NZ_CP087186:5088637-5088924 [Pseudomonas siliginis]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACCCTGCTGCTGGATGTCTTGCCCGAGCTTGGTATCAGCGTGAGCGA
ATTGGCCCGGCACCTTGGCTTTGCACGCCCGCATCTTTCGCGCGTACTGCACGGACACGCGCCGATCAGCCCGGATCTGG
CAGTACGACTTGAGCGTGCAGGGATCGGCAAGGCGCGCGTTTGGCTAGGCGTCCAAACCGACTACGATCTTTGGCAAGCG
GAGCACCGTGAGCAACCAATGATAGAACCCCTCGCAGCCCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5GET7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References