Detailed information of TA system TA183812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3839051..3840138
• Replicon: chromosome
• Accession: NZ_CP066032
• Organism: Escherichia coli strain FDAARGOS_1059

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2X3JVH3
• Locus tag: I6I16_RS18910
• Protein ID: WP_001125424.1
• Coordinates: 3839317..3840138 (+)
• Length: 274 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6I16_RS18905
• Protein ID: WP_001296726.1
• Coordinates: 3839051..3839317 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I16_RS18905	3839051..3839317	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6I16_RS18910	3839317..3840138	+	822	WP_001125424.1	HipA N-terminal domain-containing protein	Toxin
I6I16_RS18915	3840450..3840658	+	209	Protein_3689	helix-turn-helix transcriptional regulator	-
I6I16_RS18920	3841090..3841653	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
I6I16_RS18925	3842014..3842724	+	711	WP_001195165.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	3839051..3855414	16363

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 274 a.a.
• Molecular weight: 30477.19 Da
• Isoelectric Point: 10.2419

>T183812 WP_001125424.1 NZ_CP066032:3839317-3840138 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRL
TPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVK
TSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 822 bp

>T183812 NZ_CP087186:c2286971-2286687 [Pseudomonas siliginis]
ATGCAGATTAAGTGGCGACCCAAGGCCCGGGTCGAACTCTCGAAAATCCTGAAGTACATTGGCGAGCGAAATTTTGAAGC
GGCGACTGCACTTCACAAGTCCGTCGTGAAAGCTACATCTGCGCTTTGTTGGCATCCACACCTGTATCGCAAAGGCCGCT
CTCCCGGCACTCGAGAGATTGTGGTAAGCCCCAACTATCTCGTCGTTTATCAAGTGGCGGACCACATTGAGATTGTGAGC
ATCCTGCATGCGCGTCAGGAGTACCCTCGACGCGACCCCGGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT183812 WP_001296726.1 NZ_CP066032:3839051-3839317 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT183812 NZ_CP087186:c2287167-2286961 [Pseudomonas siliginis]
ATGATCGACCCGTCCTTGATCGACCCACTATGCCCGGTTGTTTCGGATCTTGATCCCGAGGAGCAGGCTGCGAGTTATGA
CCGCTGGTTTCGGGCCGAAGTACAGGCCTCTCTCGATGATCCGCGTCCGAGTATTCCTCATGAGCAAGTGATGGAGGAAA
TGAATGCCTTGATGGAATCTATGCGCAAAAGCGCAGATGCAGATTAA

Structures

Toxin

• AlphaFold DB: A0A2X3JVH3