183793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1540565..1541196 Replicon chromosome
Accession NZ_CP066032
Organism Escherichia coli strain FDAARGOS_1059

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag I6I16_RS07250 Protein ID WP_001259385.1
Coordinates 1540565..1540840 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag I6I16_RS07255 Protein ID WP_000593554.1
Coordinates 1540837..1541196 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I16_RS07235 1535569..1536636 + 1068 WP_000361467.1 HlyD family secretion protein -
I6I16_RS07240 1536633..1539368 + 2736 WP_000149167.1 ribosome-associated ATPase/putative transporter RbbA -
I6I16_RS07245 1539368..1540492 + 1125 WP_001216257.1 ABC transporter permease -
I6I16_RS07250 1540565..1540840 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
I6I16_RS07255 1540837..1541196 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6I16_RS07260 1541246..1542106 - 861 WP_001131783.1 class II aldolase -
I6I16_RS07265 1542138..1542407 - 270 WP_000933060.1 HPr family phosphocarrier protein -
I6I16_RS07270 1542397..1543905 - 1509 WP_001298718.1 carbohydrate kinase -
I6I16_RS07275 1543898..1545256 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
I6I16_RS07280 1545333..1545614 - 282 WP_000084023.1 PTS sugar transporter subunit IIB -
I6I16_RS07285 1545611..1546084 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1532948..1541196 8248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T183793 WP_001259385.1 NZ_CP066032:1540565-1540840 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T183793 NZ_CP087182:c6950232-6949888 [Pseudomonas protegens]
ATGCCAACACTGACAATCCGCTACACCGAAACCGCACAGCAAAGCATTGAAGACCAGATTGTGCATCTGGCCGACTATAG
CGACCTTAAGTCTGCCTTTGAGCGGTTGGAAGCTGTGATTGACGCTCTTCAGGACAAGCTCTTGTCCGCCCCGCTAGGCT
ACCCAGTCAGCCCTCAAGCAAGCGACCTGGGCATCTTGCATTACCGTGAGCTCAACACCGATGGATACCGGGTGTTCTAC
GAAATCGTGGATGCGGATCAGGCGATCGTGATTGGGCTGGTGCTGCGGGATAAGCAAAGCGTCGAGCAGGCACTTATTCG
TTACTGTCTGCTGCATACCGATTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT183793 WP_000593554.1 NZ_CP066032:1540837-1541196 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT183793 NZ_CP087182:c6950495-6950247 [Pseudomonas protegens]
ATGCGAGTTGAAACGGTCAGCTTTTTAAAACGATATGCCTCCGATCTGCCGTTAGAGGAGCCAATGGTCGTTACGCAAAA
CGGTGTGCCTGTTTACGTTGTCGAGTCTTACGTTGAGCGTAAGCGCCGCGACGAGGCAGTGGCGTTGGTGAAATTGCTCG
CAGTCAGTTCGCGCGAGTACGCCCAAGGCAAGCATTGTTCGACTGATGAGCTGAAGGCCCGCTTAAGCAAGAGGTTTGCC
CACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References