Detailed information of TA system TA183786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1861537..1862210
• Replicon: chromosome
• Accession: NZ_CP066026
• Organism: Brevundimonas diminuta strain FDAARGOS_1026

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6H83_RS09215
• Protein ID: WP_003165189.1
• Coordinates: 1861788..1862210 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I6H83_RS09210
• Protein ID: WP_003165190.1
• Coordinates: 1861537..1861791 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H83_RS09180	1856922..1857446	-	525	WP_128720136.1	hypothetical protein	-
I6H83_RS09185	1857777..1857854	-	78	Protein_1811	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I6H83_RS09190	1857893..1858348	-	456	WP_003169270.1	helix-turn-helix domain-containing protein	-
I6H83_RS09195	1858468..1859400	-	933	WP_003165193.1	AraC family transcriptional regulator	-
I6H83_RS09200	1859837..1860397	+	561	WP_003165192.1	sigma-70 family RNA polymerase sigma factor	-
I6H83_RS09205	1860397..1861347	+	951	WP_040345555.1	FecR domain-containing protein	-
I6H83_RS09210	1861537..1861791	+	255	WP_003165190.1	hypothetical protein	Antitoxin
I6H83_RS09215	1861788..1862210	+	423	WP_003165189.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6H83_RS09220	1862419..1862901	+	483	WP_128720135.1	STN domain-containing protein	-
I6H83_RS09225	1862943..1864315	+	1373	WP_095046155.1	IS3 family transposase	-
I6H83_RS09230	1864312..1865436	-	1125	WP_128720134.1	hypothetical protein	-
I6H83_RS09235	1865436..1866065	-	630	WP_157683871.1	lasso peptide biosynthesis B2 protein	-
I6H83_RS09240	1866145..1866279	-	135	WP_128720133.1	benenodin family lasso peptide	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1734348..1901784	167436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14745.03 Da
• Isoelectric Point: 6.4815

>T183786 WP_003165189.1 NZ_CP066026:1861788-1862210 [Brevundimonas diminuta]
MILLDTNVISETMRPEPHPDVVRWLDEQAAETLYLSSVTVAEMLFGIGVLPAGRRKDRLAAAVDGIVALFGDRILAFDLV
AARHHAALAVKARTAGKGFPTPDGYIAAIAAAHGFAVATRDVSAFAAAGLPVMNPWASPN

Nucleotide

• Length: 423 bp

>T183786 NZ_CP087182:c761967-761677 [Pseudomonas protegens]
ATGCGCACCCCAGTGACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCGTGCTGATCCGCGCCGCACTCAACGACATCGCCCGTGCCCGCGGCATGACCCAGG
TCGCCCGAGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCCCTCGGCAGCCAGGGCAACCCGGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCCCTGGGGTTGAAGATCAACGTCAGCAACGCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9159.40 Da
• Isoelectric Point: 11.3030

>AT183786 WP_003165190.1 NZ_CP066026:1861537-1861791 [Brevundimonas diminuta]
MAAVTIRNLSEETHRALKLRAASHGRSAEAEIRDILERAVRPAKRVRLGSAMAAAGRQAGVTNADVEALEQHRDRKPASP
MSFE

Nucleotide

• Length: 255 bp

>AT183786 NZ_CP087182:c762273-761971 [Pseudomonas protegens]
ATGTTCGTTTTCGAGCAGACTCCTGAGTTCAGCCGCTGGCTGCTGAACCTGAAGGACCCGCAAGGGAAAACCCGTGTACT
GGCCAGGATCCGTGCCGCACAGCTGGGCCGTTTTGGCGACTGCGAACCTGTGGGCGAAGGCGTCCACGAAATGCGCATCC
ACCGCGGCCCGGGTTACCGGGTGTACTTCTCGCGCCGCGGCAAAGTGATCTACCTGCTGTTGATCGGCGGCGACAAGGCC
ACCCAGAAACGCGATATCCAACGGGCCAGGCAACTGGCCTGCGACCTCAAGAGCGAGGGCTGA