Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 475289..475796 Replicon chromosome
Accession NZ_CP066022
Organism Fusobacterium canifelinum strain FDAARGOS_999

Toxin (Protein)


Gene name yoeB Uniprot ID U7TRZ4
Locus tag I6H56_RS02230 Protein ID WP_023037539.1
Coordinates 475536..475796 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag I6H56_RS02225 Protein ID WP_005892688.1
Coordinates 475289..475543 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H56_RS02210 472086..472448 + 363 WP_124796957.1 arsenate reductase family protein -
I6H56_RS02215 472487..473761 + 1275 WP_124796958.1 branched-chain amino acid transport system II carrier protein -
I6H56_RS02220 473787..474995 + 1209 WP_147367412.1 tyrosine--tRNA ligase -
I6H56_RS02225 475289..475543 + 255 WP_005892688.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6H56_RS02230 475536..475796 + 261 WP_023037539.1 Txe/YoeB family addiction module toxin Toxin
I6H56_RS02235 475806..476309 + 504 WP_198480885.1 GNAT family N-acetyltransferase -
I6H56_RS02240 476337..476825 + 489 WP_198480886.1 GNAT family N-acetyltransferase -
I6H56_RS02245 476822..477481 + 660 WP_147367416.1 endonuclease III -
I6H56_RS02250 477550..478743 + 1194 WP_198480887.1 cysteine desulfurase -
I6H56_RS02255 478807..479184 + 378 WP_124796962.1 Fe-S cluster assembly scaffold protein NifU -
I6H56_RS02260 479276..480574 + 1299 WP_198480888.1 D-alanyl-D-alanine carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10296.80 Da        Isoelectric Point: 9.3654

>T183784 WP_023037539.1 NZ_CP066022:475536-475796 [Fusobacterium canifelinum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFIWIIAC
KGHYEE

Download         Length: 261 bp

>T183784 NZ_CP087181:c5110285-5110058 [Pseudomonas sp. B21-031]
ATGCGCAGTCGTGAAGTAATTCAGCTTATCGAGGCAGATGGGTGGTACGAAGTAGAGGTGAAGGGCAGCCATCACCAGTT
CAGGCACCCAACCAAAAGGGGGAGGGTGACGGTTCCCCACCCTAAGAGCGATCTGCCTAAGGGCACTGTACATAGCATTT
TGAAGCAAGCTGGGCTGAAGCAGCCTAATGGCTCCAACAGCTCAAGTACCAGTGGAGACACGCAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT183784 WP_005892688.1 NZ_CP066022:475289-475543 [Fusobacterium canifelinum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp

>AT183784 NZ_CP087181:c5110061-5109654 [Pseudomonas sp. B21-031]
ATGAAATTTCCGGTCGTATTGCACAAAGACGCTGATTCGGACTACGGGGTGACCGTTCCTGATGTTCCTGGCTGCTTTTC
AGCAGGCGCCAGTGTCTCTCAGGCGTTGGAGAATGTTCAGGAGGCACTGGCGTTACATTTTGAAGGTCTGGTTGCCGATA
ACGAAGCGTTACCGCAGGCGCAAGAGATCGATGTTCATGTGGCTAACCCCGATTACCAAGGTGGGGTCTGGGCGGTCGTG
GACTTCGATGTGACCCCCTACCTTGGCAAGGCAGTGCGATTCAATGCGACGCTGCCGGAAAATTTGTTGCAACGGATCGA
TGAGAAGGTAAAGCGCGACCATAGGTATGCATCGCGTTCCGGATTTTTAGCATCGGCAGCGTTGCGAGAGCTGGCAATCG
CACACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U7TRZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A806UAF3

References