Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2724146..2724689 Replicon chromosome
Accession NZ_CP066019
Organism Cupriavidus necator strain FDAARGOS_1030

Toxin (Protein)


Gene name relE Uniprot ID Q0JYB8
Locus tag I6H87_RS31210 Protein ID WP_011617903.1
Coordinates 2724146..2724436 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R7XLV2
Locus tag I6H87_RS31215 Protein ID WP_010810750.1
Coordinates 2724423..2724689 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H87_RS31200 2720742..2722277 + 1536 WP_010810746.1 amino acid permease -
I6H87_RS31205 2722358..2724034 + 1677 WP_037024735.1 amidohydrolase family protein -
I6H87_RS31210 2724146..2724436 - 291 WP_011617903.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6H87_RS31215 2724423..2724689 - 267 WP_010810750.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6H87_RS31220 2724971..2727133 + 2163 WP_011617904.1 TonB-dependent receptor -
I6H87_RS31225 2727190..2728167 - 978 WP_010810752.1 tripartite tricarboxylate transporter substrate binding protein -
I6H87_RS31230 2728251..2729066 - 816 WP_011617905.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2677334..2724689 47355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11214.01 Da        Isoelectric Point: 10.0499

>T183781 WP_011617903.1 NZ_CP066019:c2724436-2724146 [Cupriavidus necator]
MRTIERTTQFKRDYKRELKGPFKALLQSPAGDWFAILTALASDMSLPDKFRDHALGGQWKDFRDCHVRPDLLLIYRKPDP
WTLQLVRLGSHSELAM

Download         Length: 291 bp

>T183781 NZ_CP087181:c811910-811572 [Pseudomonas sp. B21-031]
ATGAAGATCATCGCTTATCGGAACTTGGCCTGTTACCGCCTGCACACACCGAAGTGGGCGATTGCGCCAATGTCCGGAGC
GGGTGCAGCCACTCAGGGCGGCCGAGCCAACCGCAAGGGTCTGGAGGCGCTCTACCTGTCCCTGGAGCCGGCAACTGCGG
TGGCTGAGTTCCAGCAAGGTAGCCCGTTTCTACCTCCGGGCCTTCTGGTGAGCTACTCACTCACGCTGGATCTTGTGCTC
TACACGGACCAACTTCCCGCGCACGGCTCCATCACTGTGAATGACCCCCGTGGCGATCTCCCCAAGGATCAGTCTTCCTG
GCACCGACCCAAGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9489.96 Da        Isoelectric Point: 4.4692

>AT183781 WP_010810750.1 NZ_CP066019:c2724689-2724423 [Cupriavidus necator]
MSASTFVRARIDVEIKEEAAIVLEAMGLTVSDAVRMLLTRVAREKALPVELMTPNPATIASLKEARAGGLRKFGSVSDLM
ADLNDEDD

Download         Length: 267 bp

>AT183781 NZ_CP087181:c812302-811907 [Pseudomonas sp. B21-031]
ATGGCCAGCAATGCAGTATTGGAACTTCACCCCACCACTTTCGAAGGATTGATGGAAGCGCTTCGCGAAGTTAACCGGGT
CATGTTTTCCCCTGAGCGGTTCTTGAAAGTGTTCTCGATGGACCAGCAGACATTCGCGGCCCGCGCCCATGTCCATCGCA
ATACGGTGCGTAACGCCCCGGAGTCGGAAAAGATCCAGGCATACATTCGGGATGCAGTACGGGTCCTGCGCGCTTTGACC
GACATGGGTACCGAAATGACCAAGGCCATTTTCTGGTTCAAGAACGAGCCGCTGTCCACTTTCGATTACAAGACCGCAGA
AGAGGTTGTCAGCGAAGGCCGAACTGAACAATTGATCGCCTTCCTCCAGTCGTGGGAAGCCGGCGCCCAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4G011

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4FZW4

References