Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
Location | 2724146..2724689 | Replicon | chromosome |
Accession | NZ_CP066019 | ||
Organism | Cupriavidus necator strain FDAARGOS_1030 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q0JYB8 |
Locus tag | I6H87_RS31210 | Protein ID | WP_011617903.1 |
Coordinates | 2724146..2724436 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | R7XLV2 |
Locus tag | I6H87_RS31215 | Protein ID | WP_010810750.1 |
Coordinates | 2724423..2724689 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6H87_RS31200 | 2720742..2722277 | + | 1536 | WP_010810746.1 | amino acid permease | - |
I6H87_RS31205 | 2722358..2724034 | + | 1677 | WP_037024735.1 | amidohydrolase family protein | - |
I6H87_RS31210 | 2724146..2724436 | - | 291 | WP_011617903.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
I6H87_RS31215 | 2724423..2724689 | - | 267 | WP_010810750.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
I6H87_RS31220 | 2724971..2727133 | + | 2163 | WP_011617904.1 | TonB-dependent receptor | - |
I6H87_RS31225 | 2727190..2728167 | - | 978 | WP_010810752.1 | tripartite tricarboxylate transporter substrate binding protein | - |
I6H87_RS31230 | 2728251..2729066 | - | 816 | WP_011617905.1 | enoyl-CoA hydratase/isomerase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2677334..2724689 | 47355 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11214.01 Da Isoelectric Point: 10.0499
>T183781 WP_011617903.1 NZ_CP066019:c2724436-2724146 [Cupriavidus necator]
MRTIERTTQFKRDYKRELKGPFKALLQSPAGDWFAILTALASDMSLPDKFRDHALGGQWKDFRDCHVRPDLLLIYRKPDP
WTLQLVRLGSHSELAM
MRTIERTTQFKRDYKRELKGPFKALLQSPAGDWFAILTALASDMSLPDKFRDHALGGQWKDFRDCHVRPDLLLIYRKPDP
WTLQLVRLGSHSELAM
Download Length: 291 bp
>T183781 NZ_CP087181:c811910-811572 [Pseudomonas sp. B21-031]
ATGAAGATCATCGCTTATCGGAACTTGGCCTGTTACCGCCTGCACACACCGAAGTGGGCGATTGCGCCAATGTCCGGAGC
GGGTGCAGCCACTCAGGGCGGCCGAGCCAACCGCAAGGGTCTGGAGGCGCTCTACCTGTCCCTGGAGCCGGCAACTGCGG
TGGCTGAGTTCCAGCAAGGTAGCCCGTTTCTACCTCCGGGCCTTCTGGTGAGCTACTCACTCACGCTGGATCTTGTGCTC
TACACGGACCAACTTCCCGCGCACGGCTCCATCACTGTGAATGACCCCCGTGGCGATCTCCCCAAGGATCAGTCTTCCTG
GCACCGACCCAAGAGCTGA
ATGAAGATCATCGCTTATCGGAACTTGGCCTGTTACCGCCTGCACACACCGAAGTGGGCGATTGCGCCAATGTCCGGAGC
GGGTGCAGCCACTCAGGGCGGCCGAGCCAACCGCAAGGGTCTGGAGGCGCTCTACCTGTCCCTGGAGCCGGCAACTGCGG
TGGCTGAGTTCCAGCAAGGTAGCCCGTTTCTACCTCCGGGCCTTCTGGTGAGCTACTCACTCACGCTGGATCTTGTGCTC
TACACGGACCAACTTCCCGCGCACGGCTCCATCACTGTGAATGACCCCCGTGGCGATCTCCCCAAGGATCAGTCTTCCTG
GCACCGACCCAAGAGCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9489.96 Da Isoelectric Point: 4.4692
>AT183781 WP_010810750.1 NZ_CP066019:c2724689-2724423 [Cupriavidus necator]
MSASTFVRARIDVEIKEEAAIVLEAMGLTVSDAVRMLLTRVAREKALPVELMTPNPATIASLKEARAGGLRKFGSVSDLM
ADLNDEDD
MSASTFVRARIDVEIKEEAAIVLEAMGLTVSDAVRMLLTRVAREKALPVELMTPNPATIASLKEARAGGLRKFGSVSDLM
ADLNDEDD
Download Length: 267 bp
>AT183781 NZ_CP087181:c812302-811907 [Pseudomonas sp. B21-031]
ATGGCCAGCAATGCAGTATTGGAACTTCACCCCACCACTTTCGAAGGATTGATGGAAGCGCTTCGCGAAGTTAACCGGGT
CATGTTTTCCCCTGAGCGGTTCTTGAAAGTGTTCTCGATGGACCAGCAGACATTCGCGGCCCGCGCCCATGTCCATCGCA
ATACGGTGCGTAACGCCCCGGAGTCGGAAAAGATCCAGGCATACATTCGGGATGCAGTACGGGTCCTGCGCGCTTTGACC
GACATGGGTACCGAAATGACCAAGGCCATTTTCTGGTTCAAGAACGAGCCGCTGTCCACTTTCGATTACAAGACCGCAGA
AGAGGTTGTCAGCGAAGGCCGAACTGAACAATTGATCGCCTTCCTCCAGTCGTGGGAAGCCGGCGCCCAAGGATGA
ATGGCCAGCAATGCAGTATTGGAACTTCACCCCACCACTTTCGAAGGATTGATGGAAGCGCTTCGCGAAGTTAACCGGGT
CATGTTTTCCCCTGAGCGGTTCTTGAAAGTGTTCTCGATGGACCAGCAGACATTCGCGGCCCGCGCCCATGTCCATCGCA
ATACGGTGCGTAACGCCCCGGAGTCGGAAAAGATCCAGGCATACATTCGGGATGCAGTACGGGTCCTGCGCGCTTTGACC
GACATGGGTACCGAAATGACCAAGGCCATTTTCTGGTTCAAGAACGAGCCGCTGTCCACTTTCGATTACAAGACCGCAGA
AGAGGTTGTCAGCGAAGGCCGAACTGAACAATTGATCGCCTTCCTCCAGTCGTGGGAAGCCGGCGCCCAAGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T4G011 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T4FZW4 |