183777

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 1345727..1346712 Replicon chromosome
Accession NZ_CP066019
Organism Cupriavidus necator strain FDAARGOS_1030

Toxin (Protein)


Gene name ParT Uniprot ID Q0K1S1
Locus tag I6H87_RS25160 Protein ID WP_011617110.1
Coordinates 1346239..1346712 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID Q0K1S2
Locus tag I6H87_RS25155 Protein ID WP_011617109.1
Coordinates 1345727..1346242 (+) Length 172 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H87_RS25125 1341167..1341811 + 645 WP_010809399.1 TetR/AcrR family transcriptional regulator -
I6H87_RS25130 1342127..1342438 + 312 WP_011617106.1 hypothetical protein -
I6H87_RS25135 1342516..1342698 + 183 WP_010809397.1 hypothetical protein -
I6H87_RS25140 1342751..1343176 - 426 WP_035823937.1 hypothetical protein -
I6H87_RS25145 1343423..1344550 - 1128 WP_041688081.1 site-specific integrase -
I6H87_RS25150 1344664..1345629 + 966 WP_011617108.1 DNA-binding protein -
I6H87_RS25155 1345727..1346242 + 516 WP_011617109.1 DUF2384 domain-containing protein Antitoxin
I6H87_RS25160 1346239..1346712 + 474 WP_011617110.1 RES family NAD+ phosphorylase Toxin
I6H87_RS25165 1346716..1348293 - 1578 WP_011617111.1 fatty acid--CoA ligase -
I6H87_RS25170 1348526..1350796 + 2271 WP_041688083.1 ATP-dependent DNA helicase -
I6H87_RS25175 1350921..1351244 + 324 WP_010809389.1 thioredoxin family protein -
I6H87_RS25180 1351262..1351693 - 432 WP_010809388.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-152)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(44-105)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16706.95 Da        Isoelectric Point: 6.2220

>T183777 WP_011617110.1 NZ_CP066019:1346239-1346712 [Cupriavidus necator]
VRPAWRIATDTPDYTADDASGAGAKATGGRWNRQGTPLIYAASSIALACLETLVHLGSGGLPLNRYLVRIDIPDELWAAA
QKLSVDTAPVGWDAIPAGKTSLDTGEAWTAGGTSALLLVPSIVIPEEHNVLVNPAHPDAARLAYVKVRRWQYDARLV

Download         Length: 474 bp

>T183777 NZ_CP087179:c624485-624075 [Pseudomonas sp. B21-035]
ATGCTCAAGTACATGCTCGATACCAACATCTGCATCTTCACCCTCAAGAACAAGCCTCTGGTCGTACGTGAAGCATTCAA
TCGCCATTACGGCCAACTGTGCATCAGCACAGTGACGCTGATGGAATTGATGTATGGCGCTGAAAAATCCGCTGCACCTG
AACGCAATCTTGCCGTAGTCGAAGGATTCGCCGCACGCCTGGAGGTCCTCAGTTACGATGATCGTGCTGCGGCTCACAGC
GGTCAGTTGCGTGCAGAGTTGGCCCGAGCCGGAACACCGATTGGCCCCTATGACCAGATGATTGCCGGACATGCGCGTTC
ATTGGGGTTGCTACTGGTAACCAACAACATCCGCGAATTCCAGCGTGTTCCTGGGCTGCGCGTGGAAGACTGGCTCAACC
CCGCTCAATAG

Antitoxin


Download         Length: 172 a.a.        Molecular weight: 18518.17 Da        Isoelectric Point: 9.5015

>AT183777 WP_011617109.1 NZ_CP066019:1345727-1346242 [Cupriavidus necator]
MPLMLTPKGRYPLAHERPAPPELGVNNYVAVYEASLSTQGAMSIIRAIREGVPASDLNRLAESMGTTKEQLIKTLDLPRA
TVDRKARAHQNLSSEQSERVLGMARLVGQVQALVESSGDPRGFSAAQWVAQWLEQPSPALGGRRPAELMDTLAGQRIVSD
LVARMQSGAYA

Download         Length: 516 bp

>AT183777 NZ_CP087179:c624715-624485 [Pseudomonas sp. B21-035]
ATGGAGCAAGGTGCCGTCTTCAAGAGCAACCGCAGCCAAGCTGTGCGCCTGCCCAAGTCCGTAGCCCTGCCAGAGGATGT
CAAACGCGTGGATATAGTCGCAGTGGGGCGAACCCGAATTATTTCTCCCTCCGGTGAAGCCTGGGACAGCTGGTTCGAAG
GTCAGGATGTCAGCCCGGACTTCATGGCCGAACGTGAGCAAGACACCGATCAGGAGCGTGAGGGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KPF4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KN77

References