Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 725035..725714 Replicon chromosome
Accession NZ_CP066019
Organism Cupriavidus necator strain FDAARGOS_1030

Toxin (Protein)


Gene name vapC Uniprot ID Q0K3B6
Locus tag I6H87_RS22325 Protein ID WP_011616765.1
Coordinates 725286..725714 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R7XJ21
Locus tag I6H87_RS22320 Protein ID WP_010811708.1
Coordinates 725035..725289 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H87_RS22300 720694..721155 - 462 WP_010811712.1 MaoC family dehydratase N-terminal domain-containing protein -
I6H87_RS22305 721152..722375 - 1224 WP_011616763.1 CoA transferase -
I6H87_RS22310 722482..723372 + 891 WP_011616764.1 LysR family transcriptional regulator -
I6H87_RS22315 723392..724588 - 1197 WP_010811709.1 helix-turn-helix transcriptional regulator -
I6H87_RS22320 725035..725289 + 255 WP_010811708.1 plasmid stabilization protein Antitoxin
I6H87_RS22325 725286..725714 + 429 WP_011616765.1 type II toxin-antitoxin system VapC family toxin Toxin
I6H87_RS22330 725742..728111 - 2370 WP_041688010.1 mechanosensitive ion channel family protein -
I6H87_RS22335 728376..729158 + 783 WP_011616767.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 14984.23 Da        Isoelectric Point: 4.6158

>T183776 WP_011616765.1 NZ_CP066019:725286-725714 [Cupriavidus necator]
MIVLDTNVISEAMKPEPADAVRGWLNDQAAETLYLSSVTLAELLFGIGALPADRRRAMLAAALDGLVTLFEGRILPFDTN
AARHYAELAVAARSRGRGLPAPDGYIAAIAAANGMMVATRDVSPFEAAGLQVLNPWQAPPPS

Download         Length: 429 bp

>T183776 NZ_CP087178:1018350-1018649 [Pseudomonas sp. B21-036]
ATGAGCGTTACATTGATTCCATTCGACATGGCGGCACTGCTTGATAGTGATGAAGCCATCAGCGAGTACTTGTCTCAGGT
GCTGGCAGAGGGCGACAGCGACGAGCTTTTACGTGCAATAGGGTACGTGGCCAAAGCGCGCGGAATGTCGCTGGTTGCCA
AAGAGACTGGATTGGGAAGAGAGAGCCTTTACAAGGCCTTCGCGCCAGGCGCCAAGCCTCGTTTCGATACGGTGCTGAAG
GTGATGCATGCGCTGGGAATCGAACTCTGTGCGCGCTCGCATCGAGGGGCTTCGGTGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9130.53 Da        Isoelectric Point: 10.9254

>AT183776 WP_010811708.1 NZ_CP066019:725035-725289 [Cupriavidus necator]
MPILTVRNVPDDVHRALRVRAARNGRSTEAEVRQILASAVMPQKRVRLGDALAMLGREIGLSNADVEAIGQGKDKAAAEP
VRFE

Download         Length: 255 bp

>AT183776 NZ_CP087178:1018054-1018347 [Pseudomonas sp. B21-036]
GTGATCTATTCCATAGAACAGACTTTGGCATTCAGCGGCTGGCTTCTGGCGCTACGCGATGTACGAGCGAGGATCGCCAT
TGGTCGACGCATCGAACGTGCGCTTGCGGGCAACTTGGGGGATACGAAGGCGGTTGGTGATGGTGTTTCAGAGATGCGCA
TCGATTCCGGCCCAGGCTATCGGGTGTACTTCACCGTGCGTAGCGGCGTAGCAATCTTGTTGCTGACAGGCGGGGACAAG
TCTTCTCAAGCAGCAGATATCCGGATGGCCAAGCGGTTGGCCAAAGAGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KMR8

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KMW2

References