Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2400229..2400868 Replicon chromosome
Accession NZ_CP066018
Organism Cupriavidus necator strain FDAARGOS_1030

Toxin (Protein)


Gene name vapC Uniprot ID Q0K7L6
Locus tag I6H87_RS11200 Protein ID WP_011615916.1
Coordinates 2400229..2400645 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R7XDA2
Locus tag I6H87_RS11205 Protein ID WP_010813840.1
Coordinates 2400632..2400868 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H87_RS11180 2395790..2396179 + 390 WP_011615918.1 hypothetical protein -
I6H87_RS11185 2396243..2397073 + 831 WP_010813844.1 formate dehydrogenase accessory sulfurtransferase FdhD -
I6H87_RS11190 2397170..2397736 + 567 WP_010813843.1 dCTP deaminase -
I6H87_RS11195 2397887..2400160 + 2274 WP_011615917.1 arginine/lysine/ornithine decarboxylase -
I6H87_RS11200 2400229..2400645 - 417 WP_011615916.1 type II toxin-antitoxin system VapC family toxin Toxin
I6H87_RS11205 2400632..2400868 - 237 WP_010813840.1 plasmid stability protein StbC Antitoxin
I6H87_RS11210 2401212..2402927 - 1716 WP_010813839.1 TRAP transporter large permease subunit -
I6H87_RS11215 2402940..2403542 - 603 WP_011615914.1 TRAP transporter small permease subunit -
I6H87_RS11220 2403832..2405250 - 1419 WP_010813837.1 argininosuccinate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15333.56 Da        Isoelectric Point: 6.7296

>T183774 WP_011615916.1 NZ_CP066018:c2400645-2400229 [Cupriavidus necator]
VYLIDTNVISETRKRERANPGVRAFFRQAAREGAALYLSALTVGELQRGVALIRHRGDTAQAELLEQWLATVLEDFGRLV
LPVDADVAQVWGQLRAPRPEHALDKFIAATALIHDLTIVTRNVEDFRGTGAMLLNPFT

Download         Length: 417 bp

>T183774 NZ_CP087178:c241592-241278 [Pseudomonas sp. B21-036]
ATGCTCTTCATCGAAACAAGCGTATTTACCAGCGACGTTTCAAGCCATCTCGATGATCACGAGTACCTGTCGCTTCAGGT
GTATCTTGCCGAGCACCCTGAAGCAGGTGACCTGATCGAAGATACCGGCGGGCTGCGAAAAATTCGATGGGCAGCAAAAA
GCAAAGGAAAAAGCGGCGGGGTTCGAGTGATCTATTACTACGCCGTGTCAGCCAGCCAGATCCGTTTGCTGCTTATCTAC
CGCAAAGGCATCCACGATACATTGACTAAAAAACAGAAAGCCGTACTTCGAAGCCTCAACCAAGGGTGGAAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8508.59 Da        Isoelectric Point: 5.8236

>AT183774 WP_010813840.1 NZ_CP066018:c2400868-2400632 [Cupriavidus necator]
MATLLVRGIDESLVQRLRERAVANGRSAEAEHRAILAQALGGTRRRSLAEVLASIPDVGQDADFERIQNPGEAPRVFD

Download         Length: 237 bp

>AT183774 NZ_CP087178:c241278-240991 [Pseudomonas sp. B21-036]
ATGGACAGGAATCTTTTCGGTCGCCTCGTTGACAGCATGACCGAGATGGCTGAAATCGATCGTGGGGAGCGCAAACCTTC
ACGCGAGTTCAAGGTAGACGCCATGCAGGTCAGGGCCATACGCGAGGCAACCGGGCTTACCCAGGAAAGATTTGCGCAGT
GTATCGATGTACCGCTGGGTACGTTGCGCAATTGGGAGCAAGGACGCCGTGCTCCAGAAGGGCCAGCACGGGCACTGCTG
CGTGCGATTCACAATGACCCGGAACATGTTCTGGCCGCATTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KI19

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KI67

References