183772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5270..5858 Replicon plasmid unnamed
Accession NZ_CP066017
Organism Acinetobacter baumannii strain FDAARGOS_1036

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag I6H93_RS19495 Protein ID WP_000438826.1
Coordinates 5270..5557 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag I6H93_RS19500 Protein ID WP_001983304.1
Coordinates 5544..5858 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H93_RS19465 755..928 - 174 WP_001282484.1 hypothetical protein -
I6H93_RS19470 928..1299 - 372 WP_000504218.1 hypothetical protein -
I6H93_RS19475 2509..3459 + 951 WP_001205343.1 replication initiation protein RepM -
I6H93_RS19480 3452..4027 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
I6H93_RS19485 4047..4190 + 144 WP_001125246.1 hypothetical protein -
I6H93_RS19490 4379..4897 - 519 WP_000447193.1 sel1 repeat family protein -
I6H93_RS19495 5270..5557 + 288 WP_000438826.1 BrnT family toxin Toxin
I6H93_RS19500 5544..5858 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
I6H93_RS19505 5986..8397 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
I6H93_RS19510 8702..9163 + 462 WP_000761346.1 DIP1984 family protein -
I6H93_RS19515 9486..9659 - 174 WP_001282484.1 hypothetical protein -
I6H93_RS19520 9659..10030 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10308 10308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T183772 WP_000438826.1 NZ_CP066017:5270-5557 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T183772 NZ_CP087177:4924786-4925040 [Pseudomonas moraviensis]
ATGAAAATCGAGTTCACGCCCACAGGCTGGGAAGACTATTTGTGGTTTCAGCAAAACGACAAGGCTGGGCTCAAGCGCAT
CAATCTTCTGATCAAAGCAATCAAGCGCGAACCGTTTGAGGGTGTCGGTAAACCAGAGGCGCTCAAACATAATATGAGCG
GCCTCTGGTCACGCCGAGTAACGGCCGAACATCGTCTGGTGTACAGGGTTGAGGACGGCGAAATCTGCGTCATCAGTTGC
CGGTATCACTATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT183772 WP_001983304.1 NZ_CP066017:5544-5858 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT183772 NZ_CP087177:4924535-4924789 [Pseudomonas moraviensis]
ATGCAAACCATCAACTACACCACCGCCCGTGCGCATTTGGCCGAGACGATGGACCGTGTCAATGAAGATCGTGCGCCGCT
ATTGGTCACTCGGCAGAAAGGTGAACCAGTAGTGATGATGTCTTTGGCCGAATACAACGCATTGGAAGAAACAGCGTATT
TGCTTCGCTCCCCCGCCAACGCCGAACGGCTGATGAAATCCATCGGTGAGTTACGCGCCGGCAAAGCCAAAGTCAGGCAA
TTGATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References