Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2606044..2606681 Replicon chromosome
Accession NZ_CP066015
Organism Kytococcus sedentarius strain FDAARGOS_1061

Toxin (Protein)


Gene name vapC Uniprot ID C7NJK8
Locus tag I6I18_RS12460 Protein ID WP_012801756.1
Coordinates 2606289..2606681 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6I18_RS12455 Protein ID WP_041290823.1
Coordinates 2606044..2606292 (+) Length 83 a.a.

Genomic Context

I6I18_RS12445I6I18_RS12455I6I18_RS12460I6I18_RS12495I6I18_RS12435I6I18_RS12440I6I18_RS12450I6I18_RS12465I6I18_RS12470I6I18_RS12475I6I18_RS12480I6I18_RS12485I6I18_RS12490I6I18_RS12500
Location: 2603813..2605135 (1323 bp)
Type: Others
Protein ID: WP_049758591.1
Location: 2606044..2606292 (249 bp)
Type: Antitoxin
Protein ID: WP_041290823.1
Location: 2606289..2606681 (393 bp)
Type: Toxin
Protein ID: WP_012801756.1
Location: 2610242..2610637 (396 bp)
Type: Others
Protein ID: Protein_2445
Location: 2601807..2603051 (1245 bp)
Type: Others
Protein ID: WP_012801751.1
Location: 2603048..2603362 (315 bp)
Type: Others
Protein ID: WP_169307763.1
Location: 2605170..2605982 (813 bp)
Type: Others
Protein ID: WP_012801754.1
Location: 2606686..2607456 (771 bp)
Type: Others
Protein ID: WP_012801757.1
Location: 2607575..2608234 (660 bp)
Type: Others
Protein ID: WP_012801758.1
Location: 2608284..2608625 (342 bp)
Type: Others
Protein ID: WP_012801759.1
Location: 2608661..2609377 (717 bp)
Type: Others
Protein ID: WP_081439726.1
Location: 2609319..2609981 (663 bp)
Type: Others
Protein ID: WP_012801761.1
Location: 2610025..2610147 (123 bp)
Type: Others
Protein ID: WP_115306804.1
Location: 2610671..2611081 (411 bp)
Type: Others
Protein ID: Protein_2446
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I18_RS124352601807..2603051-1245WP_012801751.1cupin-like domain-containing protein-
I6I18_RS124402603048..2603362-315WP_169307763.1hypothetical protein-
I6I18_RS124452603813..2605135+1323WP_049758591.1replicative DNA helicase-
I6I18_RS124502605170..2605982-813WP_012801754.1fused MFS/spermidine synthase-
I6I18_RS124552606044..2606292+249WP_041290823.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
I6I18_RS124602606289..2606681+393WP_012801756.1type II toxin-antitoxin system VapC family toxinToxin
I6I18_RS124652606686..2607456-771WP_012801757.1DUF1524 domain-containing protein-
I6I18_RS124702607575..2608234-660WP_012801758.1maleylpyruvate isomerase family mycothiol-dependent enzyme-
I6I18_RS124752608284..2608625-342WP_012801759.1DUF2200 domain-containing protein-
I6I18_RS124802608661..2609377-717WP_081439726.1HNH endonuclease-
I6I18_RS124852609319..2609981-663WP_012801761.1FMN-binding protein-
I6I18_RS124902610025..2610147-123WP_115306804.1Ltp family lipoprotein-
I6I18_RS124952610242..2610637+396Protein_2445transposase family protein-
I6I18_RS125002610671..2611081-411Protein_2446Gfo/Idh/MocA family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13744.49 Da        Isoelectric Point: 4.3094

>T183770 WP_012801756.1 NZ_CP066015:2606289-2606681 [Kytococcus sedentarius]
VIVDSSALVAILLAEPERQALLEAIQQAPEAAMTAASYLEVGMVVDGRGNPVLSRQYDALLEALGIEVVDTTAEQARVAR
AAHRDFGRGSGHPARLNFGDCLSYAAAVQDGVPLLFTGDDFIHTDVTPAR

Download         Length: 393 bp

>T183770 NZ_CP087177:3439107-3439328 [Pseudomonas moraviensis]
ATCGAATACGTTGAACAACGCAACACTGTCGCTTCACTTGCACTGCACCAAAAGCTCAGCGCGGCAGCGCGAAGGCTTTC
CTGGATACCGCATGGTTTCCGCTCCGGCCGAATACCGGGCACTCGCGAAATGGTCATTAACTCGAATTATTTACTGGTCT
ATCGGGTGACAGACCAGATCAATATTCTGACCGTATTGCACGCCCGTAAAAAATATCCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9004.15 Da        Isoelectric Point: 4.6158

>AT183770 WP_041290823.1 NZ_CP066015:2606044-2606292 [Kytococcus sedentarius]
MALTIKNDRVCDLAREAAQRSGQSQVSVIEQALERYLADHAEPVGRRVDEVLARIDASLAPGDAAAMRVELDRLYDERGL
PA

Download         Length: 249 bp

>AT183770 NZ_CP087177:3438875-3439069 [Pseudomonas moraviensis]
ATGAGCGCTGAACTTTCACTTATCGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGAGCTATGACCGTTGGTATCGGGC
CAAGGTACAAGCCGCACTTGATGATCCACGCCCGCCTGTTCCCCACGACGAGGCAATGGTGCTGCTAGGCCAGATGCTGG
AAGAGAGGCGCAAGAATCGACGCGCTGCCGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC7NJK8

Antitoxin

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Source
ID
Structure
No matching records found

References