Detailed information of TA system TA183768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2153768..2154425
• Replicon: chromosome
• Accession: NZ_CP066015
• Organism: Kytococcus sedentarius strain FDAARGOS_1061

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6I18_RS10240
• Protein ID: WP_198479761.1
• Coordinates: 2154018..2154425 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C7NG62
• Locus tag: I6I18_RS10235
• Protein ID: WP_015780397.1
• Coordinates: 2153768..2153998 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I18_RS10225	2151830..2153023	+	1194	WP_015780395.1	Fic family protein	-
I6I18_RS10230	2153065..2153646	+	582	WP_015780396.1	dihydrofolate reductase family protein	-
I6I18_RS10235	2153768..2153998	+	231	WP_015780397.1	hypothetical protein	Antitoxin
I6I18_RS10240	2154018..2154425	+	408	WP_198479761.1	PIN domain-containing protein	Toxin
I6I18_RS10245	2154628..2155161	+	534	WP_015780399.1	hypothetical protein	-
I6I18_RS10250	2155217..2155384	-	168	WP_015780400.1	hypothetical protein	-
I6I18_RS10255	2155444..2155764	+	321	WP_015780401.1	transposase	-
I6I18_RS10260	2155962..2156417	+	456	WP_081439878.1	IS3 family transposase	-
I6I18_RS10265	2156398..2156733	+	336	WP_081439879.1	integrase core domain-containing protein	-
I6I18_RS10270	2157459..2157608	+	150	WP_015780402.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15039.91 Da
• Isoelectric Point: 6.7619

>T183768 WP_198479761.1 NZ_CP066015:2154018-2154425 [Kytococcus sedentarius]
VNTLIALLDIDHRDHEAAHRWAEERLSNGWATCATTQMGFLRVISQPGYPSPITVDEAGRLLRRATDHPSHEYWSSEPQP
CAGSVSLDVITGHRQITDAYLLALAVHQNGCLVTFDRRITTRHVPGAGQEHLVRL

Nucleotide

• Length: 408 bp

>T183768 NZ_CP087177:1768192-1768404 [Pseudomonas moraviensis]
GTGCAGAGCAGGCTATTGATGAAGGAGCTGGAGGAGGCTGGCTGGACGTTGGATCGGGTTACCGGCAGTCATCACATCTT
CACTCATCGTTACAACCCGAACACGATTGCCGTCCCGCATCCGAAAAAGGATTTACCACTGGGGACAGTCACAAGCATCA
GGCGGCGCGCGGGGTTGTTCAGCCCGCCAACCCGTCATGAAGGAGATCCGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8195.17 Da
• Isoelectric Point: 4.5535

>AT183768 WP_015780397.1 NZ_CP066015:2153768-2153998 [Kytococcus sedentarius]
MRTTLTIEDDVLQAVKDRARARGTTAGQELSALARAALSAPTFVDVGERNGLPVLQHRGEPVTREQVEALLDEDPA

Nucleotide

• Length: 231 bp

>AT183768 NZ_CP087177:1768404-1768808 [Pseudomonas moraviensis]
ATGCAATATCCCATCTGCATCGAGTGGGGTGACGAGAACACCGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCAGA
CACGGCCGGGGACAGCTTCGAGGAGGCTTACAACGCGGCCGTGGAAGTCGCGCACCTGATGCTGCAAGAAATCGCGGCGG
CCGGGCAGGCGATTCCGATGCCGACCTCGGCAGCGGCGCATCGCAGCCATCCGGATTTTGCCGGGATGGGCTGGGGCATG
CTGGAGCTGGATATCTCGCCGTATCTGGGCAAGACCGAGAAGGTCAACGTTACGCTGCCTGGCTATGTGATTCAGCGTAT
TGATCGCTATGTGCGCGAGCACAACGTCAAAAGCCGCTCCTCGTTTCTGGCGGATGCGGCGATGGAGAAACTGGTGCGGT
ATTGA

Structures

Antitoxin

• AlphaFold DB: C7NG62