Detailed information of TA system TA183767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2075454..2075937
• Replicon: chromosome
• Accession: NZ_CP066015
• Organism: Kytococcus sedentarius strain FDAARGOS_1061

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7NFN2
• Locus tag: I6I18_RS09825
• Protein ID: WP_015780317.1
• Coordinates: 2075454..2075720 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: I6I18_RS09830
• Protein ID: WP_015780318.1
• Coordinates: 2075704..2075937 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I18_RS09800	2071921..2073054	-	1134	Protein_1918	ISL3 family transposase	-
I6I18_RS09805	2073091..2074440	-	1350	WP_015779415.1	IS256 family transposase	-
I6I18_RS09810	2074502..2074687	-	186	Protein_1920	ISL3 family transposase	-
I6I18_RS09815	2075164..2075310	+	147	WP_169307799.1	hypothetical protein	-
I6I18_RS09820	2075315..2075452	+	138	WP_015780316.1	hypothetical protein	-
I6I18_RS09825	2075454..2075720	-	267	WP_015780317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I18_RS09830	2075704..2075937	-	234	WP_015780318.1	ribbon-helix-helix protein, CopG family	Antitoxin
I6I18_RS09835	2076029..2076541	-	513	WP_169307800.1	hypothetical protein	-
I6I18_RS09840	2076704..2077603	+	900	WP_015780320.1	1,4-dihydroxy-2-naphthoate polyprenyltransferase	-
I6I18_RS09845	2077823..2078410	+	588	WP_015780321.1	hypothetical protein	-
I6I18_RS09850	2078607..2079410	+	804	WP_143827386.1	hypothetical protein	-
I6I18_RS09855	2079425..2079778	-	354	WP_015780323.1	DUF4229 domain-containing protein	-
I6I18_RS09860	2079782..2080639	-	858	WP_172465380.1	c-type cytochrome biogenesis protein CcsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9964.50 Da
• Isoelectric Point: 8.0650

>T183767 WP_015780317.1 NZ_CP066015:c2075720-2075454 [Kytococcus sedentarius]
MAWTVEVSATARKALKKLDPPVARRIVRFLRELEALDDPRARGKALTGVLSGLWRYRVGDHRVICDVDDEVLVVHVIEVG
HRSSVYDD

Nucleotide

• Length: 267 bp

>T183767 NZ_CP087177:c1767543-1766968 [Pseudomonas moraviensis]
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTCTTATATCCGGCCCCTTTGAGAGACTTCCTTATGTGGCT
CGCGTTGTCTGGGCTGTATCGAGCTCGCTGGACTCAGGAAATACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGAACCTGGCCATTCCAGATGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGTCTGACGCTGCCTGATGAGAACGACCGCCATGTTCTGGCGGCCGCTATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCTCCTGTCATCTCGCGCCATATGGCATCGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTTCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCCCAAAGCCAGCGACGGCAATTGAAAACG
CCCACTGTGGAGGTGGACAAATATCTTGGCTTTCTCCAGCGGCAAGGCTTGGTCGAATCGGTAAAGGCGTTAGGTAACTA
TCGTGCGATTCTCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8649.65 Da
• Isoelectric Point: 4.6412

>AT183767 WP_015780318.1 NZ_CP066015:c2075937-2075704 [Kytococcus sedentarius]
MTVATSVKLSDETGRKLEQLAAATGRSKSYYLREAVETHIDRLLYEYGIVQRVEDVRAGREATYGLDEVEADLGLDR

Nucleotide

• Length: 234 bp

>AT183767 NZ_CP087177:c1768007-1767540 [Pseudomonas moraviensis]
ATGCCCACTCCAATTCCTTCCACTACAAATTTGCCAGTTGAACGCGAAGTCAAAGCCGCGATTGAAGGCCAGCGAACCCT
CACCGCTTTCCTCGCCACAGGTTTCGATACCCAGCGAATCCAGATTTTTGATGAGCAGAATGAAGCCCACAGCGTCGAAC
TGCCAACGTCGGCATTGCGCTTGCTAAGCGATATCCTCGCAGCGCTGGCGGAGGGCAACGCTGTGAAGGTCGTGCCGATC
CATGCCGAGCTGACCACTCAAGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGACGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA

Structures

Toxin

• AlphaFold DB: C7NFN2