Detailed information of TA system TA183760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 553894..554423
• Replicon: chromosome
• Accession: NZ_CP066013
• Organism: Staphylococcus equorum strain FDAARGOS_1068

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K7S376
• Locus tag: I6I25_RS02915
• Protein ID: WP_002511418.1
• Coordinates: 554061..554423 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: J9GY23
• Locus tag: I6I25_RS02910
• Protein ID: WP_002507108.1
• Coordinates: 553894..554064 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I25_RS02885	549645..550124	+	480	WP_021339947.1	PH domain-containing protein	-
I6I25_RS02890	550117..551622	+	1506	WP_021339948.1	PH domain-containing protein	-
I6I25_RS02895	551615..552151	+	537	WP_002507105.1	PH domain-containing protein	-
I6I25_RS02900	552184..552534	+	351	WP_021339949.1	holo-ACP synthase	-
I6I25_RS02905	552658..553806	+	1149	WP_198456447.1	alanine racemase	-
I6I25_RS02910	553894..554064	+	171	WP_002507108.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
I6I25_RS02915	554061..554423	+	363	WP_002511418.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
I6I25_RS02920	554782..555783	+	1002	WP_002507111.1	PP2C family protein-serine/threonine phosphatase	-
I6I25_RS02925	555863..556189	+	327	WP_002511417.1	anti-sigma factor antagonist	-
I6I25_RS02930	556191..556673	+	483	WP_002507113.1	anti-sigma B factor RsbW	-
I6I25_RS02935	556648..557418	+	771	WP_002507114.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13432.59 Da
• Isoelectric Point: 10.2178

>T183760 WP_002511418.1 NZ_CP066013:554061-554423 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Nucleotide

• Length: 363 bp

>T183760 NZ_CP087176:228741-228923 [Pseudomonas sp. B21-040]
ATGCGAAGTCGGGAAATGATCAGGATGATCGAGGAGGATGGTTGGTATCTGGTGGCCGTAAAAGGCAGCCACCATCAGTA
CAAGCATTTGTATAAGTCAGGCAGGGTAACGATCAAGCACCCTGATTCGGATCTTCCAAAAGGGACGATCAACAGCATAT
TGAAACAGGCGGGTCTGAAATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6305.92 Da
• Isoelectric Point: 4.0121

>AT183760 WP_002507108.1 NZ_CP066013:553894-554064 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Nucleotide

• Length: 171 bp

>AT183760 NZ_CP087176:228983-229384 [Pseudomonas sp. B21-040]
ATGAAATTCCCGGTCGTTCTGCATAAGGATGCCGACTCAGAATACGGAGTGATTATCCCGGACGTACCGGGCTGCTTCTC
CGCAGGCGGTACTGTGGCGCAGGCATTTGAAAACGTAAAAGAAGCGTTGTCTTTGCACTATGAAGGTCTGGTGGCCGATG
GTGATCCGCTGCCGCAGGTGCGTGAAATCGATGCTCACCTCGATAACCCGGATTACGCGGGCGGTGTGTGGGGAGTGGTC
GAGTTTGATATCACGCCTTATTTCGGCAAATCAGTGCGCTTCAATGCCACGTTGCCTGAACAGTTGCTTGAGCGTATCGA
CCAGACAGTCAGCCGCGACCGGCGATATAGCTCAAGATCGGGATTTTTGGCGGCTGCTGCGCTGAGAGAATTGTCGGCGT
AA

Structures

Toxin

• AlphaFold DB: K7S376

Antitoxin

• AlphaFold DB: J9GY23