Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 542425..542945 Replicon chromosome
Accession NZ_CP066013
Organism Staphylococcus equorum strain FDAARGOS_1068

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag I6I25_RS02855 Protein ID WP_031266142.1
Coordinates 542733..542945 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag I6I25_RS02850 Protein ID WP_002507096.1
Coordinates 542425..542718 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I25_RS02825 537562..538353 + 792 WP_031266140.1 hydroxyethylthiazole kinase -
I6I25_RS02830 538353..538991 + 639 WP_021339941.1 thiamine phosphate synthase -
I6I25_RS02835 539079..539948 + 870 WP_002507093.1 membrane protein insertase YidC -
I6I25_RS02840 540019..540669 - 651 WP_021339942.1 HD domain-containing protein -
I6I25_RS02845 540797..542281 - 1485 WP_021339943.1 cardiolipin synthase -
I6I25_RS02850 542425..542718 + 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6I25_RS02855 542733..542945 + 213 WP_031266142.1 heavy-metal-associated domain-containing protein Toxin
I6I25_RS02860 543159..543299 + 141 WP_002507098.1 hypothetical protein -
I6I25_RS02865 543455..544657 - 1203 WP_002507099.1 rod shape-determining protein RodA -
I6I25_RS02870 544932..546002 + 1071 WP_002507100.1 D-alanine--D-alanine ligase -
I6I25_RS02875 546015..547370 + 1356 WP_198456446.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T183759 WP_031266142.1 NZ_CP066013:542733-542945 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

>T183759 NZ_CP087175:c3532008-3531727 [Pseudomonas sp. B21-041]
ATGACCTATGAGCTGGAGTTTTCTGAAAAGGCCTGGAAAGAATGGGAGAAGCTGGGCGCAGGTCTACGAGATCAGTTCAA
GAAAAAACTAGCGGAGCGGCTGCTTAATCCACATGTACCGGCGGATCGGCTAAAAGGCCTGGGTAACGCATACAAAATAA
AGCTGCGAAGCGCCGGATATCGCTTGGTGTATCGCGTCAAGGATGAAGTGTTGGTTGTCACGGTGATAGCCGTAGGCAAG
CGAGAGCGAAGCCAAATATATACAGAGGCTGCCAAGCGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT183759 WP_002507096.1 NZ_CP066013:542425-542718 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT183759 NZ_CP087175:c3532246-3531998 [Pseudomonas sp. B21-041]
ATGGCACACATCGTTCTTTCTCACGTAGTAGCGAGTATTTCCGAATTGAAAAAAAATCCGATGGGCACCGTAGCTGCAGG
AGGTGGACGCTCTGTAGCGATTCTCAACCGAAATGAACCAGCGTTTTATTGCGTACCTGCCAAAGAGTACGAGGCAATGA
TGACGCGTCTTGATGATCTGGAGTTGATCGCGCTTTGCAAGGAGCGAGAAAACGACCCCACCATCAAGGTCTCAATAGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References