Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 34798..35323 Replicon plasmid unnamed3
Accession NZ_CP066011
Organism Salmonella enterica strain FDAARGOS_1067

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag I6I24_RS24365 Protein ID WP_001159863.1
Coordinates 34798..35103 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag I6I24_RS24370 Protein ID WP_000813641.1
Coordinates 35105..35323 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I24_RS24330 30168..30728 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
I6I24_RS24335 31457..31942 - 486 WP_000905606.1 membrane protein -
I6I24_RS24340 31936..32445 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
I6I24_RS24345 32449..33162 - 714 Protein_39 EAL domain-containing protein -
I6I24_RS24350 33171..33953 - 783 WP_000082169.1 site-specific integrase -
I6I24_RS24355 33988..34509 - 522 WP_000198608.1 hypothetical protein -
I6I24_RS24360 34506..34796 - 291 WP_001266176.1 hypothetical protein -
I6I24_RS24365 34798..35103 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
I6I24_RS24370 35105..35323 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
I6I24_RS24375 35999..36520 + 522 WP_010999942.1 hypothetical protein -
I6I24_RS24380 37004..37300 + 297 WP_001687482.1 hypothetical protein -
I6I24_RS24385 37794..38783 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
I6I24_RS24390 39042..39486 - 445 Protein_48 site-specific integrase -
I6I24_RS24395 39655..40036 - 382 Protein_49 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93851 93851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T183757 WP_001159863.1 NZ_CP066011:c35103-34798 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T183757 NZ_CP087175:c2343361-2343077 [Pseudomonas sp. B21-041]
ATGCAGATTAAGTGGCGACCCAAGGCTCGGGTCGAACTCTCGAAAATCCTGAAGTACATTGGCGAGCGAAATTTTGTAGC
GGCGACTGCACTTCACAAGTCCGTCGTAAAAACTACATCTGCGCTTTGTTGGCATCCACACCTGTATCGCAAAGGCCGCT
CTCCCGGCACTCGAGAGATTGTGGTAAGCCCGAACTATCTCGTCGTTTATCAAGTGGCGGATCAAATTGAGATTGTGAGC
ATCTTGCATGCGCGTCAGGAGTACCCTCGACGCGACCCCGGTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT183757 WP_000813641.1 NZ_CP066011:c35323-35105 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT183757 NZ_CP087175:c2343557-2343351 [Pseudomonas sp. B21-041]
ATGATCGACCCGTCCTTGATCGACCCACTGTGCCCGGTTGTTTCGGATCTTGATCCCGAGGAACAGGCTGCAAGTTATGA
CCGTTGGTTTCGGGCCGAAGTACAGGCCTCTCTCGATGATCCGCGCCCGAGTATTCCCCATGAGCAAGTGATGGAGGAAA
TCAACGCCTTGATGGAATCAATGCGCAAAAGCGCTGATGCAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References