Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 74..621 Replicon plasmid unnamed2
Accession NZ_CP066010
Organism Salmonella enterica strain FDAARGOS_1067

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag I6I24_RS23660 Protein ID WP_000969996.1
Coordinates 340..621 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag I6I24_RS23655 Protein ID WP_000079928.1
Coordinates 74..343 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I24_RS23655 74..343 + 270 WP_000079928.1 hypothetical protein Antitoxin
I6I24_RS23660 340..621 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I24_RS23665 661..1509 + 849 WP_001057996.1 3'-5' exonuclease -
I6I24_RS23670 1626..2099 + 474 WP_001334658.1 hypothetical protein -
I6I24_RS23675 2576..2842 - 267 WP_000627831.1 hypothetical protein -
I6I24_RS23680 2842..3336 - 495 WP_001442119.1 hypothetical protein -
I6I24_RS23685 3392..3994 - 603 WP_000517689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86768 86768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T183756 WP_000969996.1 NZ_CP066010:340-621 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T183756 NZ_CP087175:1831368-1831580 [Pseudomonas sp. B21-041]
GTGCAAAGCAGGTTATTGATCAAGGAGCTGGAGGAGGCGGGTTGGACGCTGGACCGGATTACCGGCAGTCATCACATTTT
CAGGCACCGTTACAACCCTTACACGATTCCCGTTCCTCATCCGAAAAAGGATTTGCCGTTGGGGACAGTCAAAAGCATCA
GGAGACGTGCCGGGTTGTACAACCCGCCAGCCAGTTTCGAAGGAGATCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT183756 WP_000079928.1 NZ_CP066010:74-343 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT183756 NZ_CP087175:1831580-1831984 [Pseudomonas sp. B21-041]
ATGCAATATCCAATCTGTATCGAGTGGGGAGACGAGAACACTGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACAGCAGGGGATAGCTTTGAAGATGCCTACAAGGCGGCAGTTGAAGTCGCCCACATCATGCTGCAGGAGATTGCGGCGG
ACGGGGAGTCGATTCCTATGCCGACTTCGGCATCCGCTCATCGCAGTAATCCGGACTTTGCCGACATGGGATGGGGCATG
CTCGAGCTGGACATTTCGCCCTATCTCGGCAAGACCGAGAAGGTCAACGTAACGCTGCCCGGTTATGTGATTCAGCGCAT
CGATCGTTATGTGCGCGAACACAACGTCAAAAGCCGCTCCTCCTTTCTGGCAGACGCGGCGATGGAGAAACTGGTTCGCT
ATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References