Detailed information of TA system TA183755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 6735319..6737002
• Replicon: chromosome
• Accession: NZ_CP066006
• Organism: Delftia acidovorans strain FDAARGOS_997

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A7T4ENJ6
• Locus tag: I6H54_RS30620
• Protein ID: WP_034389871.1
• Coordinates: 6735319..6736173 (+)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: F6ALN8
• Locus tag: I6H54_RS30625
• Protein ID: WP_012202883.1
• Coordinates: 6736196..6737002 (+)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H54_RS30595	6731188..6731679	+	492	WP_016449824.1	Lrp/AsnC family transcriptional regulator	-
I6H54_RS30600	6731761..6732351	+	591	WP_013804518.1	TetR/AcrR family transcriptional regulator	-
I6H54_RS30605	6732488..6733372	+	885	WP_016449823.1	NAD(P)-dependent oxidoreductase	-
I6H54_RS30610	6733395..6734591	+	1197	WP_034398088.1	MFS transporter	-
I6H54_RS30615	6734774..6735304	+	531	WP_012202881.1	cupin domain-containing protein	-
I6H54_RS30620	6735319..6736173	+	855	WP_034389871.1	alpha/beta fold hydrolase	Toxin
I6H54_RS30625	6736196..6737002	+	807	WP_012202883.1	IclR family transcriptional regulator	Antitoxin
I6H54_RS30630	6737057..6737854	+	798	WP_034389872.1	aspartate dehydrogenase	-
I6H54_RS30635	6737966..6738721	+	756	WP_034389873.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
I6H54_RS30640	6739114..6739362	-	249	WP_034389875.1	hypothetical protein	-
I6H54_RS30645	6740016..6740786	+	771	WP_012202888.1	SDR family oxidoreductase	-
I6H54_RS30650	6740799..6741686	+	888	WP_034389876.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (43-270)

Antitoxin

• Transcription regulator IclR, C-terminal (137-255)

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 29672.03 Da
• Isoelectric Point: 7.4023

>T183755 WP_034389871.1 NZ_CP066006:6735319-6736173 [Delftia acidovorans]
MTAQTLQRMEQRLQAQFPEHLIALPGGAQVAWREAGDTASDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDAPGYGR
STPLAPDAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVRQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLAPLLT

Nucleotide

• Length: 855 bp

>T183755 NZ_CP087175:c1531044-1530865 [Pseudomonas sp. B21-041]
GTGAATAGCCGTTTTTTAATCGGCCAACTCGTCGCAGACGGTTGGTATCTGGTACGGATCAAAGGAAGTCACCACCACTT
CAAGCATCCGACCAAACCAGGACTGGTCACCGTGCCACATCCGAAAAAGGATCTGCTGAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGCTGCTTTGA

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29330.45 Da
• Isoelectric Point: 5.7085

>AT183755 WP_012202883.1 NZ_CP066006:6736196-6737002 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Nucleotide

• Length: 807 bp

>AT183755 NZ_CP087175:c1530828-1530421 [Pseudomonas sp. B21-041]
ATGCTCTACCCGATTGCGATTTCAATTGGCGATGACCATCACGCCTGGGGTGTAGAAGTCCCGGACATTCCTGGATGCTT
TTCCGCAGGAGAGGATCTGGACGATGCCGTCGCCATGGCTCGCGAAGCCATCGAAGGTCATTTCGAGATTCTCGCGGACG
ACGACGCCCCCATTCCAGCGGCCAGCAAATTGAGCCTGCACGTGGCCAACCCGAAATACGCCGGTTGTGCATGGGCCGTG
GTGGATATCGATGTGCTCAAGTATTTGGGCAAAGCCCAGAAGCTCAACATCACCCTGCCGGGCCACCTGCTCAATCGCAT
TGATGAGTATGTGTTGCATCACCCGGAAGAGAAAAGCCGTTCCGGGTTTCTGGCTTCGGCAGCGTTGAAGGTGTTGCAGC
AGGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A031HDN8