183749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 155468..155992 Replicon chromosome
Accession NZ_CP065998
Organism Staphylococcus pseudintermedius strain FDAARGOS_1072

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag I6I29_RS00845 Protein ID WP_014613379.1
Coordinates 155639..155992 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag I6I29_RS00840 Protein ID WP_014613378.1
Coordinates 155468..155638 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I29_RS00815 151357..151830 + 474 WP_037542551.1 PH domain-containing protein -
I6I29_RS00820 151823..153352 + 1530 WP_037542554.1 PH domain-containing protein -
I6I29_RS00825 153336..153854 + 519 WP_014613375.1 PH domain-containing protein -
I6I29_RS00830 153851..154201 + 351 WP_037542556.1 holo-ACP synthase -
I6I29_RS00835 154235..155383 + 1149 WP_014613377.1 alanine racemase -
I6I29_RS00840 155468..155638 + 171 WP_014613378.1 hypothetical protein Antitoxin
I6I29_RS00845 155639..155992 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6I29_RS00850 156050..157054 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
I6I29_RS00855 157133..157459 + 327 WP_014613381.1 anti-sigma factor antagonist -
I6I29_RS00860 157459..157938 + 480 WP_031253870.1 anti-sigma B factor RsbW -
I6I29_RS00865 157913..158683 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T183749 WP_014613379.1 NZ_CP065998:155639-155992 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T183749 NZ_CP087173:955767-956060 [Pseudomonas donghuensis]
TTGAAATACAGTGTTTTGCAAACGCCCAGACTCACCTCTTGGTTGATTTCCGTACGCGACATGCGTGCAAGGGTGGCAAT
CGCACGGCGAATAGAGCGTGTAACGGCGGGAAATCTGGGAGATGTGAAGTCCGTCGGTGGTCAGGTCTGCGAGATGCGCA
TCGATGTGGGGGCGGGTTATCGGGTGTATTTCACGGCTCGGGACGGTGTAGTCATTGTTTTGTTGGCAGGTGGTGACAAG
TCATCGCAATCTGTTGATATCCAACTGGCCAGGAAGCTGGCCAAGGAAATTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT183749 WP_014613378.1 NZ_CP065998:155468-155638 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT183749 NZ_CP087173:956062-956361 [Pseudomonas donghuensis]
ATGAGTTTGTCACTTACTACGTTTGATATGGCCGCGTTGCTCGATAGCGATGAGACAATCAGCGAGTACCTTTCTCAAGT
GCTGGCGGATGGTGATCATGACGAACTGATTCGCGCCCTCGGCTATATCGCCAAGGCTCGCGGCATGAGCCAGATCGCAA
CTGCCAGTGGATTGGGGCGCGAGAGCCTGTACAAGGCGTTGACCCCCGGTGCGAAGCCTCGTTTTGACACTGTACTGAAG
GTCATCCGGGCGCTAGGGATTGATCTTCTGGCCCACCCTCATGCTTCGTCGAGACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References