183748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 139218..139739 Replicon chromosome
Accession NZ_CP065998
Organism Staphylococcus pseudintermedius strain FDAARGOS_1072

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag I6I29_RS00765 Protein ID WP_014613364.1
Coordinates 139518..139739 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag I6I29_RS00760 Protein ID WP_014613363.1
Coordinates 139218..139505 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I29_RS00735 134479..135282 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
I6I29_RS00740 135272..135910 + 639 WP_014613359.1 thiamine phosphate synthase -
I6I29_RS00745 135999..136865 + 867 WP_014613360.1 membrane protein insertase YidC -
I6I29_RS00750 136919..137575 - 657 WP_014613361.1 HD domain-containing protein -
I6I29_RS00755 137596..139086 - 1491 WP_014613362.1 cardiolipin synthase -
I6I29_RS00760 139218..139505 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6I29_RS00765 139518..139739 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
I6I29_RS00770 139743..139949 + 207 WP_014613365.1 cation transporter -
I6I29_RS00775 140050..142230 + 2181 WP_037542539.1 heavy metal translocating P-type ATPase -
I6I29_RS00780 142316..142462 + 147 WP_014613367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T183748 WP_014613364.1 NZ_CP065998:139518-139739 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T183748 NZ_CP087172:c957517-957020 [Pseudomonas sp. B21-044]
ATGACTGAAACGAGGCGCAAACCTCTATGCGTGCATGGCTGGAGTGTGTTCGCCCACCCCCTCTTTCTCGACAAGCTCGA
GGCGCTCATCGATGAAGTCGAAGTGCTTCAGAGGAAGGACCCGGTCGGGTACGTGAAGAAAAATGCGGCGAAACGATTGA
AGGCCATCAGAGGCTTGGCCTTCGACGTCATTGCCCAGGCACCCGGCAACCCGGACCATCGCATGGGTGGCACACTGGGC
GCGGAACACAAGCACTGGTTCCGTGCCAAGTTCTTCCAGCAATATCGCTTGTTTTTCCGTTATCACGCATCCAGCAAGAT
CATCGTGCTGGCGTGGGTGGACGATGACGACAGCAAACGCGCTTACGAGAGCAGCGACGACGCCTATCGAGTGTTCCGCC
GAATGCTGGGTAACGGACACCCGCCTGACGACTGGGATCAGCTGTTGCAGGAAGCTGCTGCGGCAACAGCCCGATTCAAC
GCCACCCTCAAGCGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT183748 WP_014613363.1 NZ_CP065998:139218-139505 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183748 NZ_CP087172:c957840-957514 [Pseudomonas sp. B21-044]
ATGGCTACTACCTTCGAAGCGGAATCGACTCTGACCGAGCGCTACCAGACAACGGTCCCCGAAACCGTTCGCCGCGCGTT
GGGCCTGAAAAAGCGTGACAAGATTCACTACTCGATCCGCCCTGACGGAGCAGTGATACTCACCCGCGCAGAGACAGCCG
AGGAAGACCCTGCCGTGGGGCAGTTCCTCGAATTCCTGGAGCGGGAAATCGCCACGAACCCGCAACGTTTGAAGGTTGTC
GATGCAGAGTTTGTCGCTCGCCTGGATGCACTGGTTGGCGACGTTGAAATCGATCTCGATCAACCTCTATCGGCGGACGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References