Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 6020025..6020647 Replicon chromosome
Accession NZ_CP065997
Organism Achromobacter deleyi strain FDAARGOS_1050

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6I07_RS27070 Protein ID WP_198484431.1
Coordinates 6020025..6020339 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6I07_RS27075 Protein ID WP_006394330.1
Coordinates 6020336..6020647 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I07_RS27050 6015323..6016027 - 705 WP_198484428.1 riboflavin synthase subunit alpha -
I6I07_RS27055 6016137..6017573 - 1437 WP_198487688.1 aldehyde dehydrogenase family protein -
I6I07_RS27060 6017811..6018614 + 804 WP_198484429.1 FadR family transcriptional regulator -
I6I07_RS27065 6018726..6019502 + 777 WP_198484430.1 3-oxoacyl-ACP reductase -
I6I07_RS27070 6020025..6020339 + 315 WP_198484431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I07_RS27075 6020336..6020647 + 312 WP_006394330.1 putative addiction module antidote protein Antitoxin
I6I07_RS27080 6020851..6021633 + 783 WP_198484432.1 exodeoxyribonuclease III -
I6I07_RS27090 6021923..6022618 + 696 WP_198484433.1 DUF1275 domain-containing protein -
I6I07_RS27095 6022606..6022800 - 195 WP_198484434.1 hypothetical protein -
I6I07_RS27100 6022797..6023861 - 1065 WP_198484435.1 DUF4105 domain-containing protein -
I6I07_RS27105 6023845..6024531 - 687 WP_198487689.1 MarC family NAAT transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-95)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11749.28 Da        Isoelectric Point: 5.7470

>T183747 WP_198484431.1 NZ_CP065997:6020025-6020339 [Achromobacter deleyi]
MYHIKPLPEFDAWFDTLADPATRARLLRRLEKAARGLLGDVKPVGEGVSEMREFFGPGWRTYYTEQGDVLIVMLGGGTQA
TQSRDVKHAKELARALRNDEEDQS

Download         Length: 315 bp

>T183747 NZ_CP087172:301983-302174 [Pseudomonas sp. B21-044]
ATGAACAGCCGTGAAATGATTGCTGTGATCGAGGCGGATGGCTGGTATCTGGTGCGCTCCAAAGGCAGCCACCATCATTT
CAAGCATCCTGAAAAAGCCGGGCTGGTCACCATCCCGCATCCCAAGAAAGACCTGCTGCCCGCGACTGCGGCCAGCATTC
TGCGCCAGGCACGCATCAGCTACGCCAGCTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11090.78 Da        Isoelectric Point: 8.9514

>AT183747 WP_006394330.1 NZ_CP065997:6020336-6020647 [Achromobacter deleyi]
MSKKTIKVSELPTFDPARYLRDDKDIAAYLTQVIEDGDFGELAQALGVAARARGMTQIAETAGIGRESLYKALRAGASPR
FDTIAKVCKALGVRLVVQAEHPA

Download         Length: 312 bp

>AT183747 NZ_CP087172:302191-302604 [Pseudomonas sp. B21-044]
ATGTTGTTCCCCATCGCGATCCTCCCCGGTGACGACCAGCACGCCTGGGGCGTGGAAGTCCCGGATATCCCCGGCTGCTT
TTCGGCGGGCGAAGACCTCGACGACGCTATCGCCATGGCGCGTGAAGCGATCGAAGGCCACCTCGAACTGCTGGCCCAGG
ACCAGCAGGAAATCCCCAGGGCCAGCAAGGTCGGCGTGCATGCGGCCAATCCCGCCTATGCCGGCTGCACCTGGGCATTG
ATCGATATCGACATCACCCGCTACCTGGGCAAGGCCGAGAAGCTCAACATCACCTTGCCGGCGTACCTGCTCACCCGCAT
CGACAGCTACGTACAGAACCACCCGGAGCACAAGAGCCGTTCGGGCTTCCTGGCCGAAGCGGCGCTCAGGATCCTGCAGG
GTGACGGCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References