Detailed information of TA system TA183745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2265954..2267470
• Replicon: chromosome
• Accession: NZ_CP065997
• Organism: Achromobacter deleyi strain FDAARGOS_1050

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: I6I07_RS10255
• Protein ID: WP_198486551.1
• Coordinates: 2266208..2267470 (+)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: I6I07_RS10250
• Protein ID: WP_198486550.1
• Coordinates: 2265954..2266211 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I07_RS10240	2262281..2263687	+	1407	WP_198486548.1	DKNYY domain-containing protein	-
I6I07_RS10245	2263812..2265701	+	1890	WP_198486549.1	molecular chaperone HtpG	-
I6I07_RS10250	2265954..2266211	+	258	WP_198486550.1	type II toxin-antitoxin system Y4mF family antitoxin	Antitoxin
I6I07_RS10255	2266208..2267470	+	1263	WP_198486551.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I07_RS10260	2267667..2268866	+	1200	WP_198486552.1	MFS transporter	-
I6I07_RS10265	2268870..2271038	-	2169	WP_198486553.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-95)

Antitoxin

• Transcription regulator, HipB-like (19-74)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 45566.98 Da
• Isoelectric Point: 6.7611

>T183745 WP_198486551.1 NZ_CP065997:2266208-2267470 [Achromobacter deleyi]
MSVDALDLYQADRKVGRLFDERPLRFVYDDAWLGWPAAHAIAPDIPLRDGDHAGEAVHAFFENLLPEGRLRRFLQVSRHA
TTVFGLLRSVGGDTASGLTIWPQGERPAPPRYRATTWGEIAARLQDPAQPALVAENADGARISLAGAQDKLLLMVMPDGA
PAWPEGAAPSMHILKPDIRGFDGVWSSALNETLVMQLAARLGLGVAEAGLQPDTRACLVTRYDRAPDGAAGLRRLHQLDL
CQLAGKPSDVKYEADGGPSLAQCRELLRGMGVNAADLKRFLQWVLFNLCVGNNDSHAKNLSVLQTPDGQYRLAPFYDLMC
TALYPGLACNFAFAVGGESRPGHIGRGHLDAMARELGFSPRYVAGVAQALVTELPSALETVQADLARQATAGTESTLLER
LGQWIRANTRKLAKRWELPG

Nucleotide

• Length: 1263 bp

>T183745 NZ_CP087171:3350807-3351028 [Pseudomonas atacamensis]
ATCGACTACGTAGAACAACGCAACACTGTCGCTTCAGTTGCACTGCACCAAAAGATCAGTGCCGCAGCGCGAAGGCTTTC
CTGGATACCGCATGGTTTCCGCTCCGGCCGAATACCGGGCACTCGCGAAATGGTCATTAACTCGAATTATTTACTGGTCT
ATCGGGTGACAGACCACATCAAAATTCTGACCTTGTTGCACGCCCGTAAAAAATATCCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9047.45 Da
• Isoelectric Point: 8.8566

>AT183745 WP_198486550.1 NZ_CP065997:2265954-2266211 [Achromobacter deleyi]
MPSPSSTDGASIAIHTSAELGELVKDVRRAQGLLQTDLAGLSGTGNRFVVDLERGKPTLQLQKVLDMLDLLGLEVRVGPK
RVGRP

Nucleotide

• Length: 258 bp

>AT183745 NZ_CP087171:3350575-3350769 [Pseudomonas atacamensis]
ATGAGCGCTGAACTTTCACTTATCGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGGAATACGACCTTTGGTATCGCGC
CAAGGTACAAGCCGCACTTGATGATCCACGTCCGCCTATCCCCCACGATGAGGCAATGGTGCTGCTAGGTCAGATGCTGG
AAGAGAGACGCAAGAATCGACGCGCTGCCGGTTAG